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Titolo:
Dopamine D-1 agonist activates temporal lobe structures in primates
Autore:
Black, KJ; Hershey, T; Gado, MH; Perlmutter, JS;
Indirizzi:
Edward Mallinckrodt Inst Radiol, St Louis, MO 63110 USA Edward Mallinckrodt Inst Radiol St Louis MO USA 63110 Louis, MO 63110 USA Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Neurol & Neurol Surg, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Neurol Surg, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Radiol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neurobiol, St Louis, MO 63110 USA
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 1, volume: 84, anno: 2000,
pagine: 549 - 557
SICI:
0022-3077(200007)84:1<549:DDAATL>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL GLUCOSE-UTILIZATION; C-14 2-DEOXYGLUCOSE AUTORADIOGRAPHY; ASPARTATE RECEPTOR BLOCKADE; STEADY-STATE MEASUREMENT; BLOOD-FLOW; PARKINSONS-DISEASE; BASAL GANGLIA; NITROUS-OXIDE; SUBSTANTIA-NIGRA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
114
Recensione:
Indirizzi per estratti:
Indirizzo: Black, KJ Campus Box 8134,4940 Childrens Pl, St Louis, MO 63110 USA Campus Box 8134,4940 Childrens Pl St Louis MO USA 63110 110 USA
Citazione:
K.J. Black et al., "Dopamine D-1 agonist activates temporal lobe structures in primates", J NEUROPHYS, 84(1), 2000, pp. 549-557

Abstract

Changes in the function of dopamine D-1-influenced neuronal pathways may be important to the pathophysiology of several human diseases. We recently developed methods for averaging functional imaging data across nonhuman primate subjects; in this study, we apply this method for the first time to mapbrain responses to experimental dopamine agonists in vivo. Here we report the use of positron emission tomography (PET) in seven normal baboons to measure the regional cerebral blood flow (rCBF) responses produced by an acute dose of the dopamine D-1 full agonist SKF82958. The most significant rCBFincreases were in bilateral temporal lobe, including amygdala and superiortemporal sulcus (6-17%, P< 0.001). Blood flow decreased in thalamus, pallidum, and pons (4-7%, P = 0.001). Furthermore the rCBF responses were dose-dependent and had a half-life of similar to 30 min, similar to that reportedfor the drug's antiparkinsonian effects. Absolute whole-brain blood flow did not change, suggesting that these local changes in rCBF reflect neuronalrather than direct vascular effects of the agonist. The prominent temporallobe response to a D-1 agonist supports and extends our recent observations that levodopa produces prominent amygdala activation both in humans and in other primates. We speculate that levodopa may exert its known effects onmood in humans through increased amygdala activity, mediated in part by D-1 receptors.

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Documento generato il 02/04/20 alle ore 12:44:24