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Titolo:
Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain
Autore:
Serra, M; Pisu, MG; Littera, M; Papi, G; Sanna, E; Tuveri, F; Usala, L; Purdy, RH; Biggio, G;
Indirizzi:
Univ Cagliari, Dept Expt Biol, I-09123 Cagliari, Italy Univ Cagliari Cagliari Italy I-09123 Expt Biol, I-09123 Cagliari, Italy Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 hiat, San Diego, CA 92103 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 2, volume: 75, anno: 2000,
pagine: 732 - 740
SICI:
0022-3042(200008)75:2<732:SIDIBT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; GAMMA-AMINOBUTYRIC-ACID; PITUITARY-ADRENAL AXIS; A RECEPTOR; CEREBRAL-CORTEX; MESSENGER-RNA; GABAERGIC TRANSMISSION; ARGININE-VASOPRESSIN; MAJOR DEPRESSION; REPEATED STRESS;
Keywords:
social isolation; anxiety; neurosteroids; GABA(A) receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Serra, M Univ Cagliari, Dept Expt Biol, I-09123 Cagliari, Italy Univ Cagliari Cagliari Italy I-09123 l, I-09123 Cagliari, Italy
Citazione:
M. Serra et al., "Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain", J NEUROCHEM, 75(2), 2000, pp. 732-740

Abstract

The effects of social isolation on behavior, neuroactive steroid concentrations, and GABA(A) receptor function were investigated in rats. Animals isolated for 30 days immediately after weaning exhibited an anxiety-like behavioral profile in the elevated plus-maze and Vogel conflict tests. This behavior was associated with marked decreases in the cerebrocortical, hippocampal, and plasma concentrations of pregnenolone, progesterone, allopregnanolone, and allotetrahydrodeoxycorticosterone compared with those apparent for group-housed rats; in contrast, the plasma concentration of corticosterone was increased in the isolated animals. Acute footshock stress induced greater percentage increases in the cortical concentrations of neuroactive steroids in isolated rats than in group-housed rats. Social isolation also reduced brain GABA(A) receptor function, as evaluated by measuring both GABA-evoked CI- currents in Xenopus oocytes expressing the rat receptors and tert-[S-35]butylbicyclophosphorothionate ([S-35]TBPS) binding to rat brain membranes. Whereas the amplitude of GABA-induced CI- currents did not differ significantly between group-housed and isolated animals, the potentiation of these currents by diazepam was reduced at cortical or hippocampal GABA(A) receptors from isolated rats compared with that apparent at receptors from group-housed animals. Moreover, the inhibitory effect of ethyl-beta-carboline-3-carboxylate, a negative allosteric modulator of GABA(A) receptors, on these currents was greater at cortical GABA(A) receptors from socially isolated animals than at those from group-housed rats. Finally, social isolation increased the extent of [S-35]TBPS binding to both cortical and hippocampal membranes. The results further suggest a psychological role for neurosteroids and GABA(A) receptors in the modulation of emotional behavior and mood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:57:59