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Titolo:
Molecular evolution of nitrogen fixation: The evolutionary history of the nifD, nifK, nifE, and nifN genes
Autore:
Fani, R; Gallo, R; Lio, P;
Indirizzi:
Univ Florence, Dipartimento Biol Anim & Genet, I-50125 Florence, Italy Univ Florence Florence Italy I-50125 im & Genet, I-50125 Florence, Italy Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England Univ Cambridge Cambridge England CB2 3EH net, Cambridge CB2 3EH, England
Titolo Testata:
JOURNAL OF MOLECULAR EVOLUTION
fascicolo: 1, volume: 51, anno: 2000,
pagine: 1 - 11
SICI:
0022-2844(200007)51:1<1:MEONFT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTIDINE BIOSYNTHETIC GENES; IRON-MOLYBDENUM COFACTOR; AZOTOBACTER-VINELANDII; RHODOBACTER-CAPSULATUS; NUCLEOTIDE-SEQUENCE; PROTEIN SEQUENCES; ESCHERICHIA-COLI; COMMON ANCESTOR; T-DNA; BACTERIA;
Keywords:
paralogous genes; paralogous operons; nifDK; nifEN; patchwork hypothesis; evolution of metabolic pathways; detoxyase; nitrogenase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Fani, R Univ Florence, Dipartimento Biol Anim & Genet, Via Romana 17-19, I-50125 Florence, Italy Univ Florence Via Romana 17-19 Florence Italy I-50125 ence, Italy
Citazione:
R. Fani et al., "Molecular evolution of nitrogen fixation: The evolutionary history of the nifD, nifK, nifE, and nifN genes", J MOL EVOL, 51(1), 2000, pp. 1-11

Abstract

The pairs of nitrogen fixation genes nlfDK and nifEN encode for the alpha and beta subunits: of nitrogenase and fur the two subunits of the NifNE protein complex, involved in the biosynthesis of the FeMo cofactor, respectively. Comparative analysis of the amino acid sequences of the four NifD, NifK, NifE, and NifN in several archaeal and bacterial diazotrophs showed extensive sequence similarity between them, suggesting that their encoding genesconstitute a novel paralogous gene family. We propose a two-step model to reconstruct the possible evolutionary history of the four genes. Accordingly, an ancestor gene gave rise, by an in-tandem paralogous duplication eventfollowed by divergence, to an ancestral bicistronic operon; the latter, inturn, underwent a paralogous operon duplication event followed by evolutionary divergence leading to the ancestors of the present-day nifDK and nifENoperons. Both these paralogous duplication events very likely predated theappearance of the last universal common ancestor. The possible role of theancestral gene and operon in nitrogen fixation is also discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:37:49