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Titolo:
Plasma levels of remnant particles are determined in part by variation in the APOC3 gene insulin response element and the APOCI-APOE cluster
Autore:
Waterworth, DM; Hubacek, JA; Pitha, J; Kovar, J; Poledne, R; Humphries, SE; Talmud, PJ;
Indirizzi:
RFUCLMS, Ctr Cardiovasc Genet, London WC1E 6JJ, England RFUCLMS London England WC1E 6JJ rdiovasc Genet, London WC1E 6JJ, England Inst Clin & Expt Med, Prague 14000, Czech Republic Inst Clin & Expt Med Prague Czech Republic 14000 e 14000, Czech Republic
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 7, volume: 41, anno: 2000,
pagine: 1103 - 1109
SICI:
0022-2275(200007)41:7<1103:PLORPA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; EUROPEAN ATHEROSCLEROSIS RESEARCH; RECEPTOR-RELATED PROTEIN; LIPOPROTEIN-LIPASE GENE; APOLIPOPROTEIN-E; COMMON VARIATION; HEART-DISEASE; BETA-VLDL; RISK; POLYMORPHISM;
Keywords:
insulin response element; remnant-like triglyceride; remnant-like cholesterol; hepatic lipase; lipoprotein lipase; apolipoprotein B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Waterworth, DM RFUCLMS, Ctr Cardiovasc Genet, London WC1E 6JJ, England RFUCLMS London England WC1E 6JJ London WC1E 6JJ, England
Citazione:
D.M. Waterworth et al., "Plasma levels of remnant particles are determined in part by variation in the APOC3 gene insulin response element and the APOCI-APOE cluster", J LIPID RES, 41(7), 2000, pp. 1103-1109

Abstract

Remnant particles of triglyceride-rich lipoproteins (RLP) are known to be a strong predictor of atherogenicity. The serum concentrations of remnant-like particle triglyceride (RLPTG) and remnant-like particle cholesterol (RLPC) have been determined in a representative sample of the Czech MONICA study (n = 285). The relationship was investigated between remnant particle triglyceride/ cholesterol concentrations and polymorphisms in the genes APOC3(-482C-->T/3238C-->G), APOE (epsilon 2/epsilon 3/epsilon 4), APOCI (-317-321ins), APOB (signal peptide), hepatic lipase (LIPE, -480C-->T), and lipoprotein lipase (LPL, S447X). Univariate analysis showed significant effects on RLPTG associated only with the APOE genotype (P = 0.009), the APOC3 -482C-->T genotype (P = 0.018), and the APOCI -317-321ins (P = 0.014) genotype and significant effects on RLPC with APOE (P = 0.01) and APOCI -317-321ins (P = 0.021). The raising effect of the APOE genotype for both remnant cholesterol and triglyceride was confined to the epsilon 2/4 (n = 6) and epsilon 4/4 (n = 3) groups, and thus when the epsilon 2/4 group was omitted in order to analyze by allele (epsilon 2+/epsilon 3+/epsilon 4+), significance waslost (P = 0.6). There was strong linkage disequilibrium between the APOE and APOCI alleles (chi(2), P < 0.001) and a multivariate ANOVA of RLPTG withall three significantly associated variants as factors demonstrated that while the APOC3 -482C-->T effect was independent of the others (P = 0.003), the APOCI -317-321ins and APOE effects were not. This was also true for theAPOCI -317-321ins and APOE effects on RLPC, To assess whether APOE-CI effects on RLPC were independent of their effects on total cholesterol and triglyceride levels, multiple linear regression was used. Using multiple linearregression, it appeared that the APOE-CI effects on RLPC were independent of their effects on plasma cholesterol, but the effects of APOC3 and APOE-CI on RLPTG could not be separated from their effects on plasma Tg levels. Further characterization of this remnant particle phenotype and its genetic determinants may lead to a better understanding of its metabolism and contribution to atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 13:07:59