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Titolo:
Branched-chain amino acids
Autore:
Platell, C; Kong, SE; McCauley, R; Hall, JC;
Indirizzi:
Univ Western Australia, Royal Perth Hosp, Dept Surg, Perth, WA 6000, Australia Univ Western Australia Perth WA Australia 6000 Perth, WA 6000, Australia Univ Western Australia, Fremantle Hosp, Dept Surg, Perth, WA 6009, Australia Univ Western Australia Perth WA Australia 6009 Perth, WA 6009, Australia
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
fascicolo: 7, volume: 15, anno: 2000,
pagine: 706 - 717
SICI:
0815-9319(200007)15:7<706:BAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL PARENTERAL-NUTRITION; CHRONIC HEPATIC-ENCEPHALOPATHY; ALPHA-KETOACID DEHYDROGENASE; DOUBLE-BLIND TRIAL; POSTOPERATIVE PROTEIN-SYNTHESIS; AMYOTROPHIC-LATERAL-SCLEROSIS; HUMAN GROWTH-HORMONE; SYRUP-URINE-DISEASE; SKELETAL-MUSCLE; METABOLIC SUPPORT;
Keywords:
branched-chain amino acids; catabolism; glutamine; hepatic encephalopathy; isoleucine; leucine; liver; metabolism; valine;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
111
Recensione:
Indirizzi per estratti:
Indirizzo: Hall, JC Univ Western Australia, Royal Perth Hosp, Dept Surg, Perth, WA 6000, Australia Univ Western Australia Perth WA Australia 6000 A 6000, Australia
Citazione:
C. Platell et al., "Branched-chain amino acids", J GASTR HEP, 15(7), 2000, pp. 706-717

Abstract

The branched-chain amino acids (BCAA), isoleucine, leucine and valine, areunique in that they are principally metabolized extrahepatically in the skeletal muscle. This observation led to the investigation of these nutrientsin a number of clinical scenarios. By far the most intensively studied applications for BCAA have been in patients with liver failure and/or patientsin catabolic disease states. However, the resulting studies have not demonstrated a clear clinical benefit for BCAA nutritional supplements. In patients with liver failure, the BCAA did improve nitrogen retention and proteinsynthesis, but their effect on patient outcome was less clear. Similarly, in critically ill septic patients, BCAA did not improve either survival or morbidity. The BCAA are important nutrients, and it seems that any specificbenefits associated with their use will be based upon a greater understanding of the underlying cellular biology. Potential areas of further researchmay include the combination of BCAA supplements with other anabolic factors (e.g. growth hormone) in managing patients with catabolic disease states. (C) 2000 Blackwell Science Asia Pty Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:29:18