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Titolo:
Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy
Autore:
Ashkar, AA; Di Santo, JP; Croy, BA;
Indirizzi:
Univ Guelph, Ontario Vet Coll, Dept Biomed Sci, Guelph, ON N1G 2W1, CanadaUniv Guelph Guelph ON Canada N1G 2W1 omed Sci, Guelph, ON N1G 2W1, Canada Inst Pasteur, Dept Immunol, F-75724 Paris, France Inst Pasteur Paris France F-75724 r, Dept Immunol, F-75724 Paris, France
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 2, volume: 192, anno: 2000,
pagine: 259 - 269
SICI:
0022-1007(20000717)192:2<259:IGCTIO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
METRIAL GLAND-CELLS; X DBA/2 MICE; IFN-GAMMA; MOUSE UTERUS; NK CELLS; IMPLANTATION; EXPRESSION; RECEPTOR; ANGIOGENESIS; LOCALIZATION;
Keywords:
interferon gamma signaling; uterine lymphocytes; decidual spiral arteries; bone marrow transplantation; tumor necrosis factor alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Ashkar, AA Univ Guelph, Ontario Vet Coll, Dept Biomed Sci, Guelph, ON N1G 2W1, Canada Univ Guelph Guelph ON Canada N1G 2W1 uelph, ON N1G 2W1, Canada
Citazione:
A.A. Ashkar et al., "Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy", J EXP MED, 192(2), 2000, pp. 259-269

Abstract

The dominant lymphocytes in human and murine implantation sites are transient, pregnancy-associated uterine natural killer (uNK) cells. These cells are a major source of interferon (IFN)-gamma. Implantation sites in mice lacking uNK cells (alymphoid recombinase activating gene [RAG]-2(-/-) common cytokine receptor chain gamma [gamma(c)](-/-)) or IFN-gamma signaling (IFN-gamma(-/-) or IFN-gamma R alpha(-/-)) fail to initiate normal pregnancy-induced modification of decidual arteries and display hypocellularity or necrosis of decidua. To investigate the functions of uNK cell-derived IFN-gamma during pregnancy, RAG-2(-/-)gamma(c)(-/-) females were engrafted with bone marrow from IFN-gamma(-/-) mice, IFN-gamma signal-disrupted mice (IFN-gamma R alpha(-/-) or signal transducer and activator of transcription [Stat]-1(-/-)), or from mice able to establish normal uNK cells (severe combined immunodeficient [SCID] or C57BL/6). Mated recipients were analyzed at midgestation. All grafts established uNK cells. Grafts from IFN-gamma(-/-) mice did not reverse host vascular or decidual patholoy. Grafts from all other donors promoted modification of decidual arteries and decidual cellularity. Grafts from IFN-gamma R alpha(-/-) or Stat-1(-/-) mice overproduced uNK cells, all of which were immature. Grafts from IFN-gamma(-/-), SCID, or C57BL/6 mice produced normal, mature uNK cells. Administration of murine recombinant IFN-gamma to pregnant RAG-2(-/-)gamma(c)(-/-) mice initiated decidual vessel modification and promoted decidual cellularity in the absence of uNK cells. These in vivo findings strongly suggest that uNK cell-derived IFN-gamma modifies the expression of genes in the uterine vasculature and stroma, which initiates vessel instability and facilitates pregnancy-induced remodeling of decidual arteries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 21:56:08