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Titolo:
Anatomic origin and clinical application of the widespread N18 potential in median nerve somatosensory evoked potentials
Autore:
Sonoo, M;
Indirizzi:
Teikyo Univ, Sch Med, Dept Neurol, Itabashi Ku, Tokyo 1738605, Japan Teikyo Univ Tokyo Japan 1738605 eurol, Itabashi Ku, Tokyo 1738605, Japan
Titolo Testata:
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
fascicolo: 3, volume: 17, anno: 2000,
pagine: 258 - 268
SICI:
0736-0258(200005)17:3<258:AOACAO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAR-FIELD POTENTIALS; DORSAL COLUMN NUCLEI; SHORT LATENCY POTENTIALS; NON-CEPHALIC REFERENCE; EARLY SEP COMPONENTS; BRAIN-DEAD PATIENTS; NEURAL GENERATORS; NASOPHARYNGEAL RECORDINGS; N-13 POTENTIALS; PONTINE LESION;
Keywords:
somatosensory evoked potentials; N18; cuneate nucleus; medulla oblongata; brain death;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Sonoo, M Teikyo Univ, Sch Med, Dept Neurol, Itabashi Ku, Kaga 2-11-1, Tokyo 1738605, Japan Teikyo Univ Kaga 2-11-1 Tokyo Japan 1738605 Tokyo 1738605, Japan
Citazione:
M. Sonoo, "Anatomic origin and clinical application of the widespread N18 potential in median nerve somatosensory evoked potentials", J CL NEURPH, 17(3), 2000, pp. 258-268

Abstract

N18 is a broad negativity, with a duration of approximately 20 msec after positive far-field potentials and is recorded widely over the scalp using anoncephalic reference. Its origin has been controversial but its preservation after pontine or upper medullary lesion while loss after high cervical lesions suggested its medullary origin. Comparison with animal studies and direct recording studies in humans leads the authors to conclude that N18 is most likely generated at the cuneate nucleus by primary afferent depolarization. Namely, dorsal column afferents send collaterals to interneurons within the cuneate nucleus, which in turn synapse on presynaptic terminals ofdorsal column fibers and depolarize them as a mechanism of presynaptic inhibition. In this way, an electrical sink is formed on presynaptic terminals, whereas their dorsocaudally situated axons serve as a source. The ventrorostral negative pole of the resultant dipolar potential must correspond to N18. The authors obtained a measure to evaluate medullary function objectively, and therefore N18 may be useful as a diagnostic tool for brain death. Usage of a C2S reference is essential for the accurate estimation of N18. Origins of other somatosensory evoked potential components related to the cuneate nucleus are also discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:29:08