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Titolo:
Centrally administered MTII affects feeding, drinking, temperature, and activity in the Sprague-Dawley rat
Autore:
Murphy, B; Nunes, CN; Ronan, JJ; Hanaway, M; Fairhurst, AM; Mellin, TN;
Indirizzi:
Merck Res Labs, Dept Pharmacol, Rahway, NJ 07065 USA Merck Res Labs Rahway NJ USA 07065 , Dept Pharmacol, Rahway, NJ 07065 USA Univ Bath, Dept Pharm & Phamacol, Bath BA2 7AY, Avon, England Univ Bath Bath Avon England BA2 7AY Phamacol, Bath BA2 7AY, Avon, England
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 89, anno: 2000,
pagine: 273 - 282
SICI:
8750-7587(200007)89:1<273:CAMAFD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL MELANOCORTIN RECEPTORS; AGOUTI-RELATED PROTEIN; FOOD-INTAKE; BODY-TEMPERATURE; NEUROPEPTIDE-Y; ALPHA-MSH; IN-VIVO; ANTAGONIST HS014; OBESITY; THERMOGENESIS;
Keywords:
obesity; telemetry; third ventricle; continuous physiological monitoring; melanocortin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Murphy, B Merck Res Labs, Dept Pharmacol, Bldg 80Y-145,126 E Lincoln Ave, Rahway, NJ07065 USA Merck Res Labs Bldg 80Y-145,126 E Lincoln Ave Rahway NJUSA 07065
Citazione:
B. Murphy et al., "Centrally administered MTII affects feeding, drinking, temperature, and activity in the Sprague-Dawley rat", J APP PHYSL, 89(1), 2000, pp. 273-282

Abstract

MTII, an agonist of melanocortinergic receptors, is a well-documented anoredgenic agent in rats. Many investigators have reported its effects on feeding without considering concurrent alterations in other behaviors. Accordingly, we performed studies to simultaneously measure nocturnal feeding, drinking, activity, and temperature of rats after intracerebroventricular (third ventricle) administration of a wide dose range of MTII (0.05-500 ng). We observed that MTII modulates these physiological parameters in a dose-dependent manner. Low doses of MTII (0.05 ng) caused reductions in feeding without alterations in body temperature, drinking, or activity. In contrast, hyperthermia and disrupted drinking patterns, along with food intake reductions, were evident at doses exceeding 50 ng. The fact that low doses altered only feeding, whereas higher doses affected a range of parameters, suggests that certain melanocortin-induced behavioral changes may be mediated by distinct populations of melanocortin receptors with varying affinities or thatthose changes seen at higher doses may be nonspecific in nature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 00:05:54