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Titolo:
Characterization of pharyngeal resistance during sleep in a spectrum of sleep-disordered breathing
Autore:
Tamisier, R; Pepin, JL; Wuyam, B; Smith, R; Argrod, J; Levy, P;
Indirizzi:
CNRS, UMR 5525, PRETA TIMC, Sleep Lab, Grenoble, France CNRS Grenoble France UMR 5525, PRETA TIMC, Sleep Lab, Grenoble, France Univ Hosp, Dept Resp Med, Nice, France Univ Hosp Nice FranceUniv Hosp, Dept Resp Med, Nice, France
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 89, anno: 2000,
pagine: 120 - 130
SICI:
8750-7587(200007)89:1<120:COPRDS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER AIRWAY-RESISTANCE; FLOW LIMITATION; APNEA PATIENTS; NREM SLEEP; NORMAL MEN; PRESSURE; VENTILATION; SNORERS; HUMANS; GENDER;
Keywords:
sleep-disordered breathing; upper airway; model of pressure-flow relationship;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Levy, P Hop Michalon, EFCR, Sleep & Respirat Unit, BP 217, F-38043 Grenoble 9, France Hop Michalon BP 217 Grenoble France 9 F-38043 Grenoble 9, France
Citazione:
R. Tamisier et al., "Characterization of pharyngeal resistance during sleep in a spectrum of sleep-disordered breathing", J APP PHYSL, 89(1), 2000, pp. 120-130

Abstract

Aims of the study were 1) to compare Hudgel's hyperbolic with Rohrer's polynomial model in describing the pressure-flow relationship, 2) to use this pressure-flow relationship to describe these resistances and to evaluate the effects of sleep stages on pharyngeal resistances, and 3) to compare these resistances to the pressure-to-flow ratio (Delta P/V). We studied 12 patients: three with upper airway resistance syndrome (UARS), four with obstructive sleep hypopnea syndrome (OSHS), three with obstructive sleep apnea syndrome (OSAS), and two with simple snoring (SS). Transpharyngeal pressures were calculated between choanae and epiglottis. Flow was measured by use of a pneumotachometer. The pressure-flow relationship was established by usingnonlinear regression and was appreciated by the Pearson's square (r(2)). Mean resistance at peak pressure (Rmax) was calculated according to the hyperbolic model during stable respiration. In 78% of the cases, the value of r(2) was greater when the hyperbolic model was used. We demonstrated that Rmax was in excellent agreement with P/V. UARS patients exhibited higher awake mean Rmax than normal subjects and other subgroups and a larger increase from wakefulness to slow-wave sleep than subjects with OSAS, OSHS, and SS. Analysis of breath-by-breath changes in Rmax was also a sensitive method todetect episodes of high resistance during sleep.

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Documento generato il 27/11/20 alle ore 03:12:33