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Titolo:
Postischemic recovery of heart metabolism and function: role of mitochondrial fatty acid transfer
Autore:
Montessuit, C; Papageorgiou, I; Tardy-Cantalupi, I; Rosenblatt-Velin, N; Lerch, R;
Indirizzi:
Univ Hosp Geneva, Ctr Cardiol, CH-1211 Geneva 14, Switzerland Univ Hosp Geneva Geneva Switzerland 14 l, CH-1211 Geneva 14, Switzerland
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 89, anno: 2000,
pagine: 111 - 119
SICI:
8750-7587(200007)89:1<111:PROHMA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYL-COA CARBOXYLASE; ISOLATED RAT HEARTS; OXIDATIVE-METABOLISM; GLUCOSE-UTILIZATION; ISCHEMIC-INJURY; REPERFUSION; GLYCOLYSIS; MYOCARDIUM; KINASE;
Keywords:
octanoate; palmitate; reperfusion; carnitine palmitoyltransferase I; nutritional state;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Montessuit, C Univ Hosp Geneva, Ctr Cardiol, 24 Rue Michelidu Crest, CH-1211 Geneva 14, Switzerland Univ Hosp Geneva 24 Rue Michelidu Crest Geneva Switzerland 14
Citazione:
C. Montessuit et al., "Postischemic recovery of heart metabolism and function: role of mitochondrial fatty acid transfer", J APP PHYSL, 89(1), 2000, pp. 111-119

Abstract

Postischemic recovery of contractile function is better in hearts from fasted rats than in hearts from fed rats. In this study, we examined whether feeding-induced inhibition of palmitate oxidation at the level of carnitine palmitoyl transferase I is involved in the mechanism underlying impaired recovery of contractile function. Hearts isolated from fasted or fed rats were submitted to no-flow ischemia followed by reperfusion with buffer containing 8 mM glucose and either 0.4 mM palmitate or 0.8 nM octanoate. During reperfusion, oxidation of palmitate was higher after fasting than after feeding, whereas oxidation of octanoate was not influenced by the nutritional state. In the presence of palmitate, recovery of left ventricular developed pressure was better in hearts from fasted rats. Substitution of octanoate for palmitate during reperfusion enhanced recovery of left ventricular developed pressure in hearts from fed rats. However, the chain length of the fatty acid did not influence diastolic contracture. The results suggest that nutritional variation of mitochondrial fatty acid transfer may influence postischemic recovery of contractile function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:55:38