Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Synthesis and regulation of sex hormone-binding globulin in obesity
Autore:
Hautanen, A;
Indirizzi:
Univ Helsinki, Cent Hosp, Dept Clin Chem, FIN-00290 Helsinki, Finland UnivHelsinki Helsinki Finland FIN-00290 em, FIN-00290 Helsinki, Finland
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
, volume: 24, anno: 2000, supplemento:, 2
pagine: S64 - S70
SICI:
0307-0565(200006)24:<S64:SAROSH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-RESISTANCE SYNDROME; PITUITARY-ADRENOCORTICAL FUNCTION; BODY-FAT DISTRIBUTION; HUMAN HEPATOMA-CELLS; ABDOMINAL OBESITY; PLASMA LEPTIN; CORTISOL SECRETION; ADRENAL AXIS; RISK-FACTORS; WOMEN;
Keywords:
testosterone; estradiol; androgens estrogens; HDL; insulin; cortisol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Hautanen, A Univ Helsinki, Cent Hosp, Dept Clin Chem, Haartmaninkatu 4, FIN-00290 Helsinki, Finland Univ Helsinki Haartmaninkatu 4 Helsinki Finland FIN-00290 and
Citazione:
A. Hautanen, "Synthesis and regulation of sex hormone-binding globulin in obesity", INT J OBES, 24, 2000, pp. S64-S70

Abstract

Sex hormone-binding globulin (SHBG) is a plasma glycoprotein with high binding affinity for testosterone and dihydrotestosterone and lower affinity for estradiol. SHBG is synthesized in the liver, and its plasma level is important in the regulation of plasma free and albumin-bound androgens and estrogens. Obesity and particularly excess visceral fat, known risk factors for cardiovascular and metabolic diseases, are associated with decreased testosterone levels in males and SHBG levels in both sexes. SHBG is usually positively correlated with high-density lipoprotein cholesterol and negativelycorrelated with triglyceride and insulin concentrations. A positive association between SHBG and various measures of insulin sensitivity has been demonstrated in both sexes, suggesting that decreased SHBG levels may be one of the components of the metabolic syndrome. Mle have examined pituitary-adrenocortical function, glucose tolerance, and lipoprotein and hormone levelsin a large cohort of Finnish males. Abdominal obesity appears to be associated with slight hypocortisolemia and increased sensitivity to exogenous adrenocorticotropin stimulation, which may contribute to the hyperinsulinemiaand related metabolic changes including decreased SHBG levels in males.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:29:12