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Titolo:
Activity of the hypothalamic-pituitary-adrenal axis in different obesity phenotypes
Autore:
Pasquali, R; Vicennati, V;
Indirizzi:
Univ Bologna, Dept Internal Med & Gastroenterol, Endocrinol Unit, S OrsolaM Malpighi Hosp, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 Malpighi Hosp, I-40126 Bologna, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
, volume: 24, anno: 2000, supplemento:, 2
pagine: S47 - S49
SICI:
0307-0565(200006)24:<S47:AOTHAI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-FAT DISTRIBUTION; CORTISOL SECRETION; PULSATILE;
Keywords:
cortisol; ACTH; abdominal obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Pasquali, R Dipartimento Med Interna & Gastroenterol, Via Massarenti 9, I-40138 Bologna, Italy Dipartimento Med Interna & Gastroenterol Via Massarenti 9 Bologna Italy I-40138
Citazione:
R. Pasquali e V. Vicennati, "Activity of the hypothalamic-pituitary-adrenal axis in different obesity phenotypes", INT J OBES, 24, 2000, pp. S47-S49

Abstract

Subjects with abdominal obesity are characterized by hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, which leads to a condition of 'functional hypercortisolism'. This appears to be the result of two distinct mechanisms. The first, which appears to be central in origin, is characterized by altered ACTH pulsatile secretory dynamics and by hyper-responsiveness of the HPA axis to different neuropeptides and acute or chronic stress events and, possibly, to selected dietary factors. The other appears to be located in the periphery, specifically the liver and visceral adipose tissue,and is characterized by supranormal cortisol production, whose paracrine and systemic effects remain unclear. It is suggested that increased exposureto cortisol of the body may play a fundamental role not only in the development of increased fat in abdominal/visceral depots, but also in determining all metabolic abnormalities closely related to the abdominal obesity phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 19:56:01