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Titolo:
Cardiac magnetic resonance spectroscopy: Potential clinical applications
Autore:
Neubauer, S;
Indirizzi:
Univ Oxford, Dept Cardiovasc Med, Oxford OX1 2JD, England Univ Oxford Oxford England OX1 2JD rdiovasc Med, Oxford OX1 2JD, England
Titolo Testata:
HERZ
fascicolo: 4, volume: 25, anno: 2000,
pagine: 452 - 460
SICI:
0340-9937(200006)25:4<452:CMRSPC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENERGY PHOSPHATE-METABOLISM; CREATINE-KINASE REACTION; CORONARY-ARTERY DISEASE; P-31 NMR-SPECTROSCOPY; DILATED CARDIOMYOPATHY; HUMAN-HEART; RAT-HEART; HYPERTROPHIC CARDIOMYOPATHY; MR SPECTROSCOPY; ATP RATIO;
Keywords:
MR spectroscopy; ATP; phosphocreatine; heart failure; coronary artery disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Neubauer, S John Radcliffe Hosp, Dept Cardiovasc Med, Headley Way, Oxford OX3 9DU, England John Radcliffe Hosp Headley Way Oxford England OX3 9DU ngland
Citazione:
S. Neubauer, "Cardiac magnetic resonance spectroscopy: Potential clinical applications", HERZ, 25(4), 2000, pp. 452-460

Abstract

MR spectroscopy is the only method far non-invasive detection of various aspects of cardiac metabolism in humans, While the H-1 nucleus of water and fat molecules is the signal source for MR imaging, the MR spectroscopic technique allows for the study of a number of other nuclei, such as C-13, F-19, Na-23, P-31, K-39 and Rb-87. Clinical applications presently are confinedto the P-31 nucleus. P-31-MR spectroscopy allows the non-invasive study ofcardiac high-energy phosphate metabolites ATP and phosphocreatine. The phosphocreatine/ATP ratio is considered an index of the energetic state of theheart. Possible clinical indications include heart failure, valve disease and coronary artery disease. In heart failure, the phosphocreatine/ATP ratio is reduced and correlates with clinical severity, ejection fraction and prognosis. In mitral and aortic valve disease, a reduced phosphscreatine/ATPratio may indicate the optimum timing for valve replacement. In coronary artery disease, a regional decrease of phosphocreatine during stress ("biochemical ergometry") may indicate local ischemia, Furthermore, absolute quantification of high-energy phosphates may allow diagnosis of myocardial viability Major technical developments, leading to improved spatial and temporalresolution will be necessary to establish MR spectroscopy as a routine clinical tool.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:39:44