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Titolo:
A contiguous 66-kb barley DNA sequence provides evidence for reversible genome expansion
Autore:
Shirasu, K; Schulman, AH; Lahaye, T; Schulze-Lefert, P;
Indirizzi:
John Innes Ctr Plant Sci Res, Sainsbury Lab, Norwich NR4 7UH, Norfolk, England John Innes Ctr Plant Sci Res Norwich Norfolk England NR4 7UH olk, England Univ Helsinki, Vikki Bioctr, Inst Biotechnol, Plant Genom Lab, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ab, FIN-00014 Helsinki, Finland
Titolo Testata:
GENOME RESEARCH
fascicolo: 7, volume: 10, anno: 2000,
pagine: 908 - 915
SICI:
1088-9051(200007)10:7<908:AC6BDS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLANT ARABIDOPSIS-THALIANA; CEREAL GENOMES; C-ELEGANS; BARE-1; GENES; MAIZE; RETROTRANSPOSONS; RECOMBINATION; CHROMOSOME-4; INSERTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Schulze-Lefert, P John Innes Ctr Plant Sci Res, Sainsbury Lab, Colney Lane, Norwich NR4 7UH,Norfolk, England John Innes Ctr Plant Sci Res Colney LaneNorwich Norfolk England NR4 7UH
Citazione:
K. Shirasu et al., "A contiguous 66-kb barley DNA sequence provides evidence for reversible genome expansion", GENOME RES, 10(7), 2000, pp. 908-915

Abstract

Organisms with large genomes contain vast amounts of repetitive DNA sequences, much of which is composed of retrotransposons. Amplification of retrotransposons has been postulated to be a major mechanism increasing genome size and leading to "genomic obesity. " To gain insights into the relation between retrotransposons and genome expansion in a large genome, we have studied a 66-kb contiguous sequence at the Rarl locus of barley in detail. Threegenes were identified in the 66-kb contig, clustered within an interval of18 kb. Inspection of sequences flanking the gene space unveiled four novelretroelements, designated Nikira,Sukkula, Sabrina, and BAGY-2 and several units of the known BARE-1 element. The retroelements identified are responsible For at least 15 integration events, predominantly arranged as multiplenested insertions. Strikingly, most of the retroelements exist as solo LTRs (Long Terminal Repeats), indicating that unequal crossing over and/or intrachromosomal recombination between LTRs is a common feature in barley. Ourdata suggest that intraelement recombination events deleted most of the original retrotransposon sequences, thereby providing a possible mechanism tocounteract retroelement-driven genome expansion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:59:02