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Titolo:
Leptin regulation of neuroendocrine systems
Autore:
Ahima, RS; Saper, CB; Flier, JS; Elmquist, JK;
Indirizzi:
Univ Penn, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Philadelphia,PA 19104 USA Univ Penn Philadelphia PA USA 19104 et & Metab, Philadelphia,PA 19104 USA Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 l, Boston, MA 02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA02215 USA Harvard Univ Boston MA USA 02215 s Med Ctr, Dept Med, Boston, MA02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol, Boston, MA 02215 USA Harvard Univ Boston MA USA 02215 tr, Div Endocrinol, Boston, MA 02215 USA
Titolo Testata:
FRONTIERS IN NEUROENDOCRINOLOGY
fascicolo: 3, volume: 21, anno: 2000,
pagine: 263 - 307
SICI:
0091-3022(200007)21:3<263:LRONS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; RECEPTOR MESSENGER-RNA; OBESE GENE-PRODUCT; MELANIN-CONCENTRATING HORMONE; THYROTROPIN-RELEASING-HORMONE; POLYCYSTIC-OVARY-SYNDROME; BLOOD-BRAIN-BARRIER; FOLLICLE-STIMULATING HORMONE; CENTRAL-NERVOUS-SYSTEM; IN-SITU HYBRIDIZATION;
Keywords:
obesity; feeding; dorsomedial hypothalamic nucleus; ventromedial hypothalamic nucleus; arcuate hypothalamic nucleus; OB protein;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
301
Recensione:
Indirizzi per estratti:
Indirizzo: Ahima, RS Univ Penn, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Philadelphia,PA 19104 USA Univ Penn Philadelphia PA USA 19104 , Philadelphia,PA 19104 USA
Citazione:
R.S. Ahima et al., "Leptin regulation of neuroendocrine systems", FRONT NEURO, 21(3), 2000, pp. 263-307

Abstract

The discovery of leptin has enhanced understanding of the interrelationship between adipose energy stores and neuronal circuits in the brain involvedin energy balance and regulation of the neuroendocrine axis. Leptin levelsare dependent on the status of fat stores as well as changes in energy balance as a result of fasting and overfeeding. Although leptin was initially thought to serve mainly as an anti-satiety hormone, recent studies have shown that it mediates the adaptation to fasting. Furthermore, leptin has beenimplicated in the regulation of the reproductive, thyroid, growth hormone,and adrenal axes, independent of its role in energy balance. Although it is widely known that leptin acts on hypothalamic neuronal targets to regulate energy balance and neuroendocrine function, the specific neuronal populations mediating leptin action on feeding behavior and autonomic and neuroendocrine function are not well understood. In this review, we have discussed how leptin engages arcuate hypothalamic neurons expressing putative orexigenic peptides, e.g., neuropeptide Y and agouti-regulated peptide, and anorexigenic peptides, e.g., pro-opiomelanocortin (precursor of alpha-melanocyte-stimulating hormone) and cocaine- and amphetamine-regulated transcript. We show that leptin's effects on energy balance and the neuroendocrine axis are mediated by projections to other hypothalamic nuclei, e.g., paraventricular, lateral, and perifornical areas, as well as other sites in the brainstem, spinal cord, and cortical and subcortical regions. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:35:03