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Titolo:
Evaluation of efficacy of neuroleptics in open versus double-blind trials:objective
Autore:
Pajonk, FG; Holzbach, R; Naber, D;
Indirizzi:
Univ Hamburg, Krankenhaus Eppendorf, Klin Psychiat & Psychotherapie, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 otherapie, D-20246 Hamburg, Germany
Titolo Testata:
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
fascicolo: 7, volume: 68, anno: 2000,
pagine: 313 - 320
SICI:
0720-4299(200007)68:7<313:EOEONI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
GER
Soggetto:
ADMITTED SCHIZOPHRENIC-PATIENTS; COMPARATIVE MULTICENTER; PHASE-II; COMPARING REMOXIPRIDE; CLINICAL-TRIAL; HALOPERIDOL; ZOTEPINE; DRUG; PIMOZIDE; HYPERACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Pajonk, FG Univ Hamburg, Krankenhaus Eppendorf, Klin Psychiat & Psychotherapie, Martinistr 52, D-20246 Hamburg, Germany Univ Hamburg Martinistr 52 Hamburg Germany D-20246 rg, Germany
Citazione:
F.G. Pajonk et al., "Evaluation of efficacy of neuroleptics in open versus double-blind trials:objective", F NEUR PSYC, 68(7), 2000, pp. 313-320

Abstract

Objective: Due to methodological reservations, results concerning the efficacy of neuroleptics in open trials are often regarded with doubt. Until now, there are nearly no studies comparing findings of controlled double-blind with those of open trials. Aim of this study was to investigate if results of an open or double-blind approach differ and hereby to gain informationabout the validity of open trials. Methods: After a literature research, five neuroleptics were identified for which at least 3 open and 3 double-blind trials exist which met the inclusion criteria and from which either the reduction of the BPRS (Brief Psychiatric Rating Scale)-score or the response rate could be determined. Results: There were no differences in the reduction of the BPRS-score or response rate for all 5 neuroleptics between openand double-blind trials. Furthermore, the efficacy of all 5 neuroleptics was comparable. Con-elusions: Double-blind controlled studies are essential in the investigation of new compounds. But results of methodologically wellperformed open studies are valid and deserve more attention. Preceding open trials may help in the design of double-blind studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:59:33