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Titolo:
Phenotype, immunological reactivity and cytokine production profile of Peyer's patch cells from mice immunized orally with allogeneic cells
Autore:
Fric, J; Krulova, M; Zajicova, A; Holan, V;
Indirizzi:
Acad Sci Czech Republ, Inst Mol Genet, Prague 16637 6, Czech Republic AcadSci Czech Republ Prague Czech Republic 16637 6 37 6, Czech Republic Charles Univ, Fac Sci, Prague, Czech Republic Charles Univ Prague Czech Republic niv, Fac Sci, Prague, Czech Republic
Titolo Testata:
FOLIA BIOLOGICA
fascicolo: 3, volume: 46, anno: 2000,
pagine: 119 - 125
SICI:
0015-5500(2000)46:3<119:PIRACP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORNEAL ALLOGRAFT SURVIVAL; CD4(+) T-CELLS; LYMPHOKINE PRODUCTION; TOLERANCE; ANTIGEN; INDUCTION; RESPONSES; SECRETION; TYPE-2; BETA;
Keywords:
oral immunization; Peyer's patches; phenotype; proliferation; cytokine production;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Holan, V Acad Sci Czech Republ, Inst Mol Genet, Flemingovo Nam 2, Prague 16637 6, Czech Republic Acad Sci Czech Republ Flemingovo Nam 2 Prague CzechRepublic 16637 6
Citazione:
J. Fric et al., "Phenotype, immunological reactivity and cytokine production profile of Peyer's patch cells from mice immunized orally with allogeneic cells", FOL BIOL, 46(3), 2000, pp. 119-125

Abstract

Mice of inbred strain BALB/c were immunized orally for LO consecutive dayswith fresh spleen cells from allogeneic C57BL/10 (B10) donors. The immunized mice displayed significant allotransplantation immunity ill vivo as demonstrated by resistance to the growth of allogeneic tumours induced by high doses of tumour cells, No significant changes in the proportion of the major T cell subsets in PP of immunized mice were found 1 or 7 days after the last immunization dose, However, PP cells from orally immunized mice displayed stronger proliferative response after stimulation with cells used for oral immunization than the cells from control animals. Similarly, after stimulation in vitro with specific alloantigens, PP cells from orally immunized mice produced more IFN-gamma than the cells from control recipients. On thecontrary, the production of IL-4 was significantly decreased in the immunized mice. The production of IL-2 by PP cells after oral immunization was not significantly changed and IL-10 was only slightly increased. The results thus show that oral immunization with allogeneic cells induces systemic transplantation immunity which can be demonstrated already in Peyer's patches by increased cell proliferation after immunization with specific alloantigens and by changes in cytokine production.

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Documento generato il 10/04/20 alle ore 02:36:55