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Titolo:
Cytokine release from the nasal mucosa and whole blood after experimental exposures to organic dusts
Autore:
Sigsgaard, T; Bonefeld-Jorgensen, EC; Kjaergaard, SK; Mamas, S; Pedersen, OF;
Indirizzi:
Aarhus Univ, Inst Environm & Occupat Med, DK-8000 Aarhus, Denmark Aarhus Univ Aarhus Denmark DK-8000 Occupat Med, DK-8000 Aarhus, Denmark INSERM, U485, Unite Associee Inst Pasteur, Unite Pharmacol Cellulaire, Paris, France INSERM Paris France Pasteur, Unite Pharmacol Cellulaire, Paris, France
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 1, volume: 16, anno: 2000,
pagine: 140 - 145
SICI:
0903-1936(200007)16:1<140:CRFTNM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHALED ENDOTOXIN; SWINE DUST; BRONCHIAL RESPONSIVENESS; HEALTHY-SUBJECTS; LAVAGE FLUID; INHALATION; (1->3)-BETA-D-GLUCAN; WORKERS; WASTE;
Keywords:
beta-1,3-D-glucan; cytokine release; individual susceptibility; lipopolysaccharide; nasal challenge; recycling workers; whole blood assay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Sigsgaard, T Aarhus Univ, Inst Environm & Occupat Med, Univ Pk,Bldg 180, DK-8000 Aarhus, Denmark Aarhus Univ Univ Pk,Bldg 180 Aarhus Denmark DK-8000 Denmark
Citazione:
T. Sigsgaard et al., "Cytokine release from the nasal mucosa and whole blood after experimental exposures to organic dusts", EUR RESP J, 16(1), 2000, pp. 140-145

Abstract

The aim of this study was to assess the cytokine response after nasal exposure to organic dusts. In a double blinded, crossover study five garbage workers,vith occupational airway symptoms and five healthy garbage workers were intranasally exposed to endotoxin (lipopolysaccharide LPS), beta-1,3-D-glucan (GLU), Aspergillus sp,, compost or the saline dilute for 15 min, Nasal cavity volume and nasal lavage (NAL) were performed at baseline and 3, 6, 11 h postexposure. NAL was analysed,vith differential cell counts, cysteinyl-leukotrienes, tumour necrosis factor alpha, interleukin (IL)-1 beta, IL-6 and IL-8, A whole blood assay on cytokine-release was performed,vith LPS and GLU,NAL cytokines neutrophils, lymphocytes and albumin increased significantlyat 6 h after LPS exposure. GLU induced an increase in albumin and a slightincrease in IL-1 beta 6-11 h post exposure, In the WBA a significant increase in all cytokines after exposure to LPS as well as GLU was found. Significantly more cells were seen in NAL of the control group 6 h post LPS exposure. In conclusion lipopolysaccharide is the most potent inducer of inflammation in the nasal mucosa whereas compost and beta-1,3-D-glucan only induce minor changes. This reaction to lipopolysaccharide is attenuated in workers with occupational airway symptoms. In whole blood assay, however, beta-1,3-D-glucan also induces cytokine release, indicating a different protective effect of the nasal mucosa towards lipo-polysaccharide and beta-1,3-D-glucan.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 22:18:31