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Titolo:
Acute psychological and physiological effects of MDMA ("Ecstasy") after haloperidol pretreatment in healthy humans
Autore:
Liechti, ME; Vollenweider, FX;
Indirizzi:
Univ Hosp Psychiat Zurich, Res Unit, CH-8029 Zurich, Switzerland Univ HospPsychiat Zurich Zurich Switzerland CH-8029 Zurich, Switzerland
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 10, anno: 2000,
pagine: 289 - 295
SICI:
0924-977X(200007)10:4<289:APAPEO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRIATAL DOPAMINE RELEASE; INTRAVENOUS COCAINE; MEDIATED RELEASE; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; SEROTONIN; METHYLENEDIOXYMETHAMPHETAMINE; AMPHETAMINE; VOLUNTEERS; PHARMACOKINETICS; MICRODIALYSIS;
Keywords:
3,4-methylenedioxymethamphetamine; MDMA; ecstasy; dopamine; haloperidol; humans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Liechti, ME Univ Hosp Psychiat Zurich, Res Unit, POB 68, CH-8029 Zurich, Switzerland Univ Hosp Psychiat Zurich POB 68 Zurich Switzerland CH-8029 d
Citazione:
M.E. Liechti e F.X. Vollenweider, "Acute psychological and physiological effects of MDMA ("Ecstasy") after haloperidol pretreatment in healthy humans", EUR NEUROPS, 10(4), 2000, pp. 289-295

Abstract

3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") releases serotonin anddopamine. The role for dopamine in mediating the effects of MDMA has not yet been examined in humans. We investigated the effect of pretreatment withthe dopamine D-2 antagonist haloperidol (1.4 mg i.v.) on psychological andphysiological responses to MDMA (1.5 mg/kg p.o.) in 14 healthy volunteers using a double-blind placebo-controlled within-subject design. Subjective peak effects were rated using standardised scales. The physiological effectsmeasured were blood pressure, heart rate and body temperature. Side effects were assessed during the session, and after 1 and 3 days. Haloperidol attenuated MDMA-induced positive and mania-like mood but had no reducing effect on other subjective changes or on cardiovascular effects. Results are consistent with a partial dopaminergic mediation of the euphoriant effects of MDMA. In contrast, dopamine does not seem to contribute to the physiological effects of MDMA, indicating a role for serotonin and norepinephrine. (C) 2000 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:13:29