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Titolo:
N-6-2-(4-Aminophenyl)ethyl-adenosine enhances the anticonvulsive action ofconventional antiepileptic drugs in the kindling model of epilepsy in rats
Autore:
Borowicz, KK; Kleinrok, Z; Czuczwar, SJ;
Indirizzi:
Lublin Med Unic Sch, Dept Pharmacol & Toxicol, PL-20090 Lublin, Poland Lublin Med Unic Sch Lublin Poland PL-20090 icol, PL-20090 Lublin, Poland Inst Agr Med, Dept Clin Toxicol, PL-20950 Lublin, Poland Inst Agr Med Lublin Poland PL-20950 lin Toxicol, PL-20950 Lublin, Poland
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 10, anno: 2000,
pagine: 237 - 243
SICI:
0924-977X(200007)10:4<237:NETAAO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; ADENOSINE RECEPTORS; PROTECTIVE ACTIVITY; AMINOPHYLLINE; CARBAMAZEPINE; SEIZURES; MICE; AMYGDALA; ELECTROCONVULSIONS; DIPHENYLHYDANTOIN;
Keywords:
APNEA; antiepileptic drugs; adenosine receptor; seizure; kindling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Czuczwar, SJ Lublin Med Unic Sch, Dept Pharmacol & Toxicol, Jaczewskiego 8, PL-20090 Lublin, Poland Lublin Med Unic Sch Jaczewskiego 8 Lublin PolandPL-20090 nd
Citazione:
K.K. Borowicz et al., "N-6-2-(4-Aminophenyl)ethyl-adenosine enhances the anticonvulsive action ofconventional antiepileptic drugs in the kindling model of epilepsy in rats", EUR NEUROPS, 10(4), 2000, pp. 237-243

Abstract

APNEA [(N-6-2-(4-Aminophenyl)ethyl-adenosine; a non-selective adenosine A(3) receptor agonist; 2-4 mg kg(-1)] had no significant effect on seizure parameters (seizure severity, seizure duration and afterdischarge duration) in amygdala-kindled rats. Subsequently APNEA was combined with antiepilepticdrugs administered at doses ineffective in fully kindled rats. Co-administration of APNEA (0.5-2 mg kg(-1)) with carbamazepine (2.5-20 mg kg(-1)) resulted in the significant reduction of all studied seizure parameters. Moreover, 8-cyclopentyl-1,3-dimethylxanthine 8-CPX (a selective adenosine A(1) receptor antagonist; 5 mg kg(-1)) partially reduced the anticonvulsive activity of a combination of APNEA (2 mg kg(-1)) with carbamazepine (20 mg kg(-1)), but not that of carbamazepine (20 mg kg(-1))+ APNEA (0.5 mg kg(-1)). When APNEA (2 mg kg(-1)) was combined with phenobarbital (20 mg kg(-1)), valproate (75 mg kg(-1)) or clonazepam (0.003 mg kg(-1)), seizure and afterdischarge durations were significantly shortened. 8-CPX (5 mg kg(-1)) totally reversed the APNEA (2 mg kg(-1))-induced enhancement of the anticonvulsive action of valproate. However, when the non-selective adenosine A(3) receptoragonist was administered together with diphenylhydantoin, no protection was observed in the kindling model of epilepsy. The interaction at the pharmacokinetic level can be excluded because APNEA did not interfere with the free plasma level of antiepileptics used in this study. It may be concluded that the interaction of APNEA with carbamazepine involves A(3) adenosine receptor-dependent events. (C) 2000 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:45:38