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Titolo:
Intake of flavonoids and risk of dementia
Autore:
Commenges, D; Scotet, V; Renaud, S; Jacqmin-Gadda, H; Barberger-Gateau, P; Dartigues, JF;
Indirizzi:
INSERM, U330, F-33076 Bordeaux, France INSERM Bordeaux France F-33076INSERM, U330, F-33076 Bordeaux, France
Titolo Testata:
EUROPEAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 4, volume: 16, anno: 2000,
pagine: 357 - 363
SICI:
0393-2990(200004)16:4<357:IOFARO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; POTENTIALLY ANTICARCINOGENIC FLAVONOIDS; LOW-DENSITY-LIPOPROTEIN; ALZHEIMERS-DISEASE; APOLIPOPROTEIN-E; DIETARY ANTIOXIDANTS; COGNITIVE FUNCTION; WINE CONSUMPTION; OXIDATIVE STRESS; RED WINE;
Keywords:
Alzheimer's disease; dementia; flavonoids; vitamin C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Commenges, D INSERM, U330, 146 Rue Leo Saignat, F-33076 Bordeaux, France INSERM 146 Rue Leo Saignat Bordeaux France F-33076 x, France
Citazione:
D. Commenges et al., "Intake of flavonoids and risk of dementia", EUR J EPID, 16(4), 2000, pp. 357-363

Abstract

It has been postulated that oxidative stress may play a key role in dementia. This is substantiated by the recent discovery of the protective effect of wine. In wine, the flavonoids - powerful antioxidant substances also contained in tea, fruits and vegetables - have been thought to offer such protection. We investigated whether flavonoid intake could be associated with alower incidence of dementia in a cohort of 1367 subjects above 65 years ofage (Paquid). A questionnaire was used to evaluate their intake of flavonoids and subjects were followed-up for 5 years between 1991 and 1996: 66 incident cases of dementia were observed. We estimated the relative risk (RR) of dementia according to tertiles of flavonoid intake using a Cox model. The age-adjusted RR of dementia was 0.55 for the two highest tertiles compared to the lowest (95% CI: 0.34-0.90; p = 0.02). After additional adjustment for gender, education, weight and vitamin C intake, the RR was 0.49 (95% CI: 0.26-0.92; p = 0.04). We conclude that the intake of antioxidant flavonoids is inversely related to the risk of incident dementia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 05:55:13