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Titolo:
Enhanced albuminuric response to atrial natriuretic peptide in normoalbuminuric patients with Type 1 diabetes mellitus - a pilot study
Autore:
McKenna, K; Smith, D; Moore, K; Glen, A; Kesson, CM; Thompson, CJ;
Indirizzi:
Victoria Infirm, Diabet Ctr, Glasgow G42 9TY, Lanark, Scotland Victoria Infirm Glasgow Lanark Scotland G42 9TY G42 9TY, Lanark, Scotland
Titolo Testata:
DIABETIC MEDICINE
fascicolo: 6, volume: 17, anno: 2000,
pagine: 463 - 468
SICI:
0742-3071(200006)17:6<463:EARTAN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR HYPERFILTRATION; VASCULAR-PERMEABILITY; URINARY ALBUMIN; NEPHROPATHY; RATS; MICROALBUMINURIA; PATHOGENESIS; EXCRETION; IDDM;
Keywords:
atrial natriuretic peptide; microalbuminuria; Type 1 diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Thompson, CJ Beaumont Hosp, Acad Dept Diabet, Dublin, Ireland Beaumont Hosp Dublin Ireland Dept Diabet, Dublin, Ireland
Citazione:
K. McKenna et al., "Enhanced albuminuric response to atrial natriuretic peptide in normoalbuminuric patients with Type 1 diabetes mellitus - a pilot study", DIABET MED, 17(6), 2000, pp. 463-468

Abstract

Aims To ascertain whether intravenous infusion of atrial natriuretic peptide (ANP) can induce microalbuminuria in patients with Type 1 diabetes mellitus (DM), as already demonstrated in patients with microalbuminuria, and tocompare the albuminuric response to ANP infusion in Type 1 DM and a matched group of healthy non-diabetic controls. Methods Eight normoalbuminuric DM patients participated in a three limb, randomized, double-blind, placebo-controlled study. Subjects were kept euglycaemic by insulin infusion, and subsequently water-loaded (20 ml/kg orally plus urinary losses). When in steady state, a 30-min infusion of either placebo, ANP 0.025 mu g.kg(-1).min(-1) or ANP 0.05 mu g.kg(-1).min(-1) was administered intravenously. Urine was collected every 15 min for 90 min for the estimation of albumin-creatinine ratio (ACR). In addition, eight non-diabetic volunteers received a single infusion of ANP 0.025 mu g.kg(-1).min(-1). Results ACR was unaltered by placebo in DM subjects (1.4 +/- 0.7-1.7 +/- 1.1 mg/mmol, mean +/- sd, anova, P > 0.9), and by low dose ANP in controls (1.4 +/- 0.9-2.6 +/- 1.9 mg/mmol, P = 0.4). ACR increased with low dose ANP (1.3 +/- 0.5-14.6 +/- 13.6 mg/mmol, P = 0.02), and high dose ANP (1.3 +/- 0.7-26.4 +/- 31 mg/mmol, P = 0.01) in DM subjects. The ACR response to low dose ANP was greater in the DM than control subjects (P = 0.02). Conclusions ANP increases urine albumin excretion rate in normoalbuminuricType 1 DM patients, and this effect is more pronounced than in healthy volunteers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 00:48:48