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Titolo:
In ovo time-lapse analysis after dorsal neural tube ablation shows rerouting of chick hindbrain neural crest
Autore:
Kulesa, P; Bronner-Fraser, M; Fraser, S;
Indirizzi:
CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH, Beckman Inst, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125 LTECH, Beckman Inst, Pasadena, CA 91125 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 13, volume: 127, anno: 2000,
pagine: 2843 - 2852
SICI:
0950-1991(200007)127:13<2843:IOTAAD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOX CODE; CELLS; MIGRATION; REGENERATION; RHOMBOMERES; MICROSCOPY; PLASTICITY; ORIGIN; REGION; EMBRYO;
Keywords:
neural crest; hindbrain; cell migration; in ovo; ablation; repatterning; time-lapse imaging; chick;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kulesa, P CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125 Div Biol, Pasadena, CA 91125 USA
Citazione:
P. Kulesa et al., "In ovo time-lapse analysis after dorsal neural tube ablation shows rerouting of chick hindbrain neural crest", DEVELOPMENT, 127(13), 2000, pp. 2843-2852

Abstract

Previous analyses of single neural crest cell trajectories have suggested important roles for interactions between neural crest cells and the environment, and amongst neural crest cells. To test the relative contribution of intrinsic versus extrinsic information in guiding cells to their appropriate sites, we ablated subpopulations of premigratory chick hindbrain neural crest and followed the remaining neural crest cells over time using a new inovo imaging technique. Neural crest cell migratory behaviors are dramatically different in ablated compared with unoperated embryos. Deviations from normal migration appear either shortly after cells emerge from the neural tube or en route to the branchial arches, areas where cell-cell interactionstypically occur between neural crest cells in normal embryos. Unlike the persistent, directed trajectories in normal embryos, neural crest cells frequently change direction and move somewhat chaotically after ablation, In addition, the migration of neural crest cells in collective chains, commonly observed in normal embryos, was severely disrupted. Hindbrain neural crest cells have the capacity to reroute their migratory pathways and thus compensate for missing neural crest cells after ablation of neighboring populations. Because the alterations in neural crest cell migration are most dramatic in regions that would normally foster cell-cell interactions, the trajectories reported here argue that cell-cell interactions have a key role in the shaping of the neural crest migration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:58:17