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Titolo:
Hormonal regulation of physiological cell turnover and apoptosis
Autore:
Medh, RD; Thompson, EB;
Indirizzi:
Univ Texas, Med Branch, Dept Human Biol Chem & Genet, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 l Chem & Genet, Galveston, TX 77555 USA
Titolo Testata:
CELL AND TISSUE RESEARCH
fascicolo: 1, volume: 301, anno: 2000,
pagine: 101 - 124
SICI:
0302-766X(200007)301:1<101:HROPCT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; RAT VENTRAL PROSTATE; GROWTH-FACTOR-BETA; GLUCOCORTICOID-INDUCED APOPTOSIS; CORTICOTROPIN-RELEASING-FACTOR; INDUCED THYMOCYTE APOPTOSIS; MOUSE MAMMARY-GLAND; ENDOGENOUS ENDONUCLEASE ACTIVATION; FOLLICLE-STIMULATING-HORMONE; UTERINE LUMINAL EPITHELIUM;
Keywords:
endocrine; thymocytes; breast; uterus; prostate; adipocytes; bone;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
288
Recensione:
Indirizzi per estratti:
Indirizzo: Medh, RD Univ Texas, Med Branch, Dept Human Biol Chem & Genet, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 Genet, Galveston, TX 77555 USA
Citazione:
R.D. Medh e E.B. Thompson, "Hormonal regulation of physiological cell turnover and apoptosis", CELL TIS RE, 301(1), 2000, pp. 101-124

Abstract

Physiological cell turnover plays an important role in maintaining normal tissue function and architecture. This is achieved by the dynamic balance of cellular regeneration and elimination, occurring periodically in tissues such as the uterus and mammary gland, or at constant rates in tissues such as the gastrointestinal tract and adipose tissue. Apoptosis has been identified as the prevalent mode of physiological cell loss in most tissues. Cellturnover is precisely regulated by the interplay of various endocrine and paracrine factors, which modulate tissue and cell-specific responses on proliferation and apoptosis, either directly, or by altering expression and function of key cell proliferative and/or death genes. Although recent studies have provided significant information on specific tissue systems, a clearly defined pathway that mediates cell turnover has not yet emerged for any tissue. Several similarities exist among the various tissues with regard tothe intermediates that regulate tissue homeostasis, enabling a better understanding of the general mechanisms involved in the process. Here we reviewthe mechanisms by which hormonal and cytokine factors mediate cell turnover in various tissues, emphasizing common themes and tissue-specific differences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 11:15:59