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Titolo:
Combining necrosis and platelet markers for perfecting myocardial infarction rule out: How close are we?
Autore:
Nair, GV; Gurbel, PA; Fuzaylov, SY; Davis, CJ; Ohman, EM; Bahr, RD; Christensen, RH; Serebruany, VL;
Indirizzi:
Sinai Hosp, Thrombosis Res Ctr, Baltimore, MD 21215 USA Sinai Hosp Baltimore MD USA 21215 mbosis Res Ctr, Baltimore, MD 21215 USA Duke Univ, Med Ctr, Durham, NC USA Duke Univ Durham NC USADuke Univ, Med Ctr, Durham, NC USA St Agnes Hosp, Baltimore, MD USA St Agnes Hosp Baltimore MD USASt Agnes Hosp, Baltimore, MD USA Univ Maryland, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 iv Maryland, Baltimore, MD 21201 USA
Titolo Testata:
CARDIOLOGY
fascicolo: 1-2, volume: 93, anno: 2000,
pagine: 50 - 55
SICI:
0008-6312(2000)93:1-2<50:CNAPMF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC TROPONIN-I; CREATINE-KINASE-MB; ACUTE CORONARY SYNDROMES; SOLUBLE P-SELECTIN; CHEST PAIN; INITIAL ELECTROCARDIOGRAM; BIOCHEMICAL MARKERS; RISK STRATIFICATION; MONOCLONAL-ANTIBODY; ADHESION MOLECULES;
Keywords:
acute myocardial infarction; chest pain; necrosis markers; platelets; emergency department;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Serebruany, VL Sinai Hosp, Thrombosis Res Ctr, 2401 W Belvedere Ave,Schapiro Res Bldg R 202, Baltimore, MD 21215 USA Sinai Hosp 2401 W Belvedere Ave,Schapiro Res Bldg R 202 Baltimore MD USA 21215
Citazione:
G.V. Nair et al., "Combining necrosis and platelet markers for perfecting myocardial infarction rule out: How close are we?", CARDIOLOGY, 93(1-2), 2000, pp. 50-55

Abstract

Each year, at least 5 million patients in the United States present to hospital emergency departments with the complaint of chest pain, and more than10% of them will be diagnosed with acute myocardial infarction. One of theforemost tasks of the emergency department physician is to avoid unnecessary admissions and concomitantly to minimize the number of patients discharged home inappropriately. Currently available diagnostic tools, including the electrocardiogram and myocardial markers, have several shortcomings, including low specificity, and delayed sensitivity for the timely detection of myocardial necrosis. Therefore, the search for better methods of rapidly identifying patients with unstable coronary syndromes is one of the utmost priorities of modern emergency medicine. Available biochemical diagnostic tools are discussed in this review, focusing on the potential benefits of combining myocardial necrosis markers with indicators of platelet activation. It is hypothesized that such a combined approach may be more powerful in myocardial infarction risk stratification than separate marker determination, Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:18:08