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Titolo:
Double minutes and c-MYC amplification in acute myelogenous leukemia: Are they prognostic factors?
Autore:
Bruckert, P; Kappler, R; Scherthan, H; Link, H; Hagmann, FG; Zankl, H;
Indirizzi:
Univ Kaiserslautern, Dept Human Biol & Human Genet, D-67663 Kaiserslautern, Germany Univ Kaiserslautern Kaiserslautern Germany D-67663 iserslautern, Germany Westpfalz Med Ctr, Dept Internal Med, Kaiserslautern, Germany Westpfalz Med Ctr Kaiserslautern Germany l Med, Kaiserslautern, Germany
Titolo Testata:
CANCER GENETICS AND CYTOGENETICS
fascicolo: 1, volume: 120, anno: 2000,
pagine: 73 - 79
SICI:
0165-4608(20000701)120:1<73:DMACAI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; COMPARATIVE GENOMIC HYBRIDIZATION; ACUTE NONLYMPHOCYTIC LEUKEMIA; IN-SITU HYBRIDIZATION; CHROMOSOMES; SEQUENCES; GENE; PATIENT; DIFFERENTIATION; MALIGNANCIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Bruckert, P Univ Kaiserslautern, Abt Human Biol & Humangenet, Bau 14,ErwinSchrodingerStr, D-67663 Kaiserslautern, Germany Univ Kaiserslautern Bau 14,Erwin Schrodinger Str Kaiserslautern Germany D-67663
Citazione:
P. Bruckert et al., "Double minutes and c-MYC amplification in acute myelogenous leukemia: Are they prognostic factors?", CANC GENET, 120(1), 2000, pp. 73-79

Abstract

A rnp of actue myelogenous leukemia (AML) with double minutes (dmin) and Xchromosome some loss is presented. Using comparative genomic hybridization(CGH), a region of high-level DNA amplification was detected at 8q24, the locus of the c-MYC proto-oncogene. Fluorescence in situ hybridization (FISH) with a DNA probe specific for the human c-MYC gene confirmed the extrachromosomal amplification of this proto-oncogene in the dmin of the leukemic cells. During the course of the disease, three relapses occurred; two complete remissions could be achieved by treatment with various chemotherapy regimens. The patient's survival time of 25 months was considerably longer thanin most reported cases of AML with extrachromosomal c-MYC amplification. Therefore, the present case challenges the view that the occurrence of dmin in AML is generally an indication of poor prognosis. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 02:14:01