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Titolo:
Urinary excretion of Bowman-Birk inhibitor in humans after soy consumptionas determined by a monoclonal antibody-based immunoassay
Autore:
Wan, XS; Lu, LJW; Anderson, KE; Ware, JH; Kennedy, AR;
Indirizzi:
Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 iat Oncol, Philadelphia, PA 19104 USA Univ Texas, Dept Prevent Med & Community Hlth, Med Branch, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 th, Med Branch, Galveston, TX 77555 USA
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 7, volume: 9, anno: 2000,
pagine: 741 - 747
SICI:
1055-9965(200007)9:7<741:UEOBII>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEASE INHIBITOR; CREATININE; SOYBEANS; ASSAY; EARTH; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Wan, XS Univ Penn, Dept Radiat Oncol, 195 John Morgan Bldg,3620 Hamilton Walk, Philadelphia, PA 19104 USA Univ Penn 195 John Morgan Bldg,3620 Hamilton Walk Philadelphia PA USA 19104
Citazione:
X.S. Wan et al., "Urinary excretion of Bowman-Birk inhibitor in humans after soy consumptionas determined by a monoclonal antibody-based immunoassay", CANC EPID B, 9(7), 2000, pp. 741-747

Abstract

The Bowman-Birk inhibitor (BBI) found in soybeans is a serine protease inhibitor with anticarcinogenic activity. In the present study, an ELISA for BBI mas developed with the use of a monoclonal antibody against a reduced form of BBI, This newly developed ELISA method was used to measure the urinary levels of BBI metabolites in nine human subjects after consumption of 36-oz or 60-oz soymilk (containing 105 or 175 mg of BBI) at two time points 36h apart. The results demonstrate that urinary BBI excretion rates peaked within 6 h and decreased to baseline levels within 12-24 h after soymilk ingestion. The changes in BBI:creatinine ratios in urine closely paralleled the changes in urinary BBI excretion rates after soymilk consumption. These data suggest that BBI ingested p.o. is absorbed and could be bioavailable for cancer chemoprevention in other organs in addition to those in the gastrointestinal tract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 00:06:04