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Titolo:
Changes in macrophage and lymphocyte functions in guinea-pigs after different amounts of vitamin E ingestion
Autore:
De la Fuente, M; Carazo, M; Correa, R; Del Rio, M;
Indirizzi:
Univ Complutense Madrid, Fac Biol Sci, Dept Anim Physiol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 siol, E-28040 Madrid, Spain
Titolo Testata:
BRITISH JOURNAL OF NUTRITION
fascicolo: 1, volume: 84, anno: 2000,
pagine: 25 - 29
SICI:
0007-1145(200007)84:1<25:CIMALF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE PERITONEAL-MACROPHAGES; PHAGOCYTIC FUNCTION; SUPPLEMENTATION; ANTIOXIDANTS; TOCOPHEROLS; MODULATION; WOMEN;
Keywords:
vitamin E; leucocytes; immune response; guinea-pigs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: De la Fuente, M Univ Complutense Madrid, Fac Biol Sci, Dept Anim Physiol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 drid, Spain
Citazione:
M. De la Fuente et al., "Changes in macrophage and lymphocyte functions in guinea-pigs after different amounts of vitamin E ingestion", BR J NUTR, 84(1), 2000, pp. 25-29

Abstract

Vitamin E is the main biological lipid-soluble antioxidant and plays a crucial role in the maintenance of the immune system. In the present work, twenty-one guinea-pigs (3-weeks-old) were distributed into three groups, whichduring 5 weeks ingested different amounts of vitamin E (/kg diet): 15 mg (low vitamin E diet), 150 mg (medium vitamin E diet; control) or 1500 mg (high vitamin E diet). The function of lymphocytes and macrophages were then studied. In macrophages obtained from the peritoneum several steps of the phagocytic process (chemotaxis, ingestion and superoxide anion production) were assayed, as well as chemotaxis and proliferation of peritoneal and spleen lymphocytes. The results indicate that with respect to the medium vitaminE diet, low ingestion of vitamin E causes a decrease in chemotaxis and production of superoxide anion by macrophages and an increase in the phagocytic capacity. With the high vitamin E diet an increase in macrophage and lymphocyte chemotaxis, superoxide anion production and lymphoproliferative capacity, as well as a decrease in phagocytosis, were observed. Therefore, dietsupplementation with higher than usual levels of vitamin E appears to be beneficial for the immune system.

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Documento generato il 14/08/20 alle ore 10:17:58