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Titolo:
Effects of MK-801 on D1 dopamine receptor-mediated immediate early gene expression in the dopamine-depleted striatum
Autore:
Ganguly, A; Keefe, KA;
Indirizzi:
Univ Utah, Dept Pharmacol & Toxicol, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 xicol, Salt Lake City, UT 84112 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 871, anno: 2000,
pagine: 156 - 159
SICI:
0006-8993(20000714)871:1<156:EOMODD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; INDUCED UP-REGULATION; NMDA RECEPTORS; RAT FOREBRAIN; C-FOS; NEURONS; AMPHETAMINE; PROTEIN; CALCIUM; ANTAGONISTS;
Keywords:
NMDA; basal ganglia; zif268; c-fos; Parkinson; glutamate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Keefe, KA Univ Utah, Dept Pharmacol & Toxicol, 30 South,2000 E 201, Salt Lake City, UT 84112 USA Univ Utah 30 South,2000 E 201 Salt Lake City UT USA 84112 12 USA
Citazione:
A. Ganguly e K.A. Keefe, "Effects of MK-801 on D1 dopamine receptor-mediated immediate early gene expression in the dopamine-depleted striatum", BRAIN RES, 871(1), 2000, pp. 156-159

Abstract

Previous work indicates that intrastriatal administration of MK-801 does not completely block D1 agonist-induced gene expression in dopamine-depletedrats. The present study examined the effects of systemic MK-801 on such gene expression. A low dose of MK-801 did not affect induction of c-fos or zif268. A high dose completely blocked induction of c-fos, but only slightly suppressed zif268. The data suggest that NMDA receptor activity may not always be necessary for D1-induced gene expression. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 10:07:33