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Titolo:
Time-specific effects of mono-n-butyl phthalate on the transabdominal descent of the testis in rat fetuses
Autore:
Shono, T; Kai, H; Suita, S; Nawata, H;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Paediat Surg, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 rg, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ, Grad Sch Med Sci, Dept Reprod Med, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ed, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ, Grad Sch Med Sci, Dept Dev Med, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ed, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ci, Higashi Ku, Fukuoka 8128582, Japan
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 1, volume: 86, anno: 2000,
pagine: 121 - 125
SICI:
1464-4096(200007)86:1<121:TEOMPO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULLERIAN DUCT REGRESSION; TESTICULAR DESCENT; HORMONAL-CONTROL; FETAL RATS; MICE; ASCENT; CELLS; PIG;
Keywords:
phthalate esters; transabdominal testicular descent; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Shono, T Kyushu Univ, Grad Sch Med Sci, Dept Paediat Surg, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan Kyushu Univ 3-1-1 Maidashi Fukuoka Japan 8128582 8128582, Japan
Citazione:
T. Shono et al., "Time-specific effects of mono-n-butyl phthalate on the transabdominal descent of the testis in rat fetuses", BJU INT, 86(1), 2000, pp. 121-125

Abstract

Objective To determine the time-specific effects of mono-n-butyl phthalate(MBP) on the transabdominal migration of the testis in fetal rats. Materials and methods Three groups of pregnant rats were administered MBP by stomach-tube feeding when the fetus was at 7-10 days of gestation in group 1, 11-14 days in group 2, and 15-18 days in group 3; controls (group 4) were given vehicle only from 7-18 days. At 20 days of gestation the fetuseswere obtained by Caesarean section, and the position of the testes, the development of the gubernaculum, cranial suspensory ligament and the epididymis were examined. Results The timed intervals of MBP administration showed that the maximum inhibition of transabdominal testicular descent was at 15-18 days of gestation. There was an elongated gubernaculum and hypertrophic cranial suspensory ligament in the MBP-treated rat fetuses. Furthermore, the epididymis showed a few small ducti deferentia, although there were no remarkable changes in either the Sertoli and Leydig cells in these testes. The mean (SEM) content of testicular testosterone was significantly less (P < 0.001) in the MBP-treated rats, at 50.9 (3.8) pg/ testis, than in the controls, at 676 (33.3) pg/testis. Conclusions These findings indicate that a brief exposure to MBP during fetal development can inhibit the transabdominal migration of the testis and reduce testosterone content in rats, although the relationship between migration and the testicular testosterone content remains unknown.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:52:02