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Titolo:
Long-term adaptive life functioning in relation to initiation of treatmentwith antipsychotics over the lifetime trajectory of schizophrenia
Autore:
Quinn, J; Moran, M; Lane, A; Kinsella, A; Waddington, JL;
Indirizzi:
Royal Coll Surg Ireland, Dept Clin Pharmacol, Dublin 2, Ireland Royal CollSurg Ireland Dublin Ireland 2 in Pharmacol, Dublin 2, Ireland St Davnets Hosp, Stanley Fdn Res Unit, Monaghan, Ireland St Davnets Hosp Monaghan Ireland tanley Fdn Res Unit, Monaghan, Ireland St John God Hosp, Dublin, Ireland St John God Hosp Dublin IrelandSt John God Hosp, Dublin, Ireland Dublin Inst Technol, Dept Math, Dublin, Ireland Dublin Inst Technol Dublin Ireland Technol, Dept Math, Dublin, Ireland
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 48, anno: 2000,
pagine: 163 - 166
SICI:
0006-3223(20000715)48:2<163:LALFIR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLOGICAL SOFT SIGNS; COGNITIVE IMPAIRMENT; GENDER DIFFERENCES; INTERVENTION; PSYCHOSIS; DURATION; DISEASE; SCALE;
Keywords:
schizophrenia; adaptive life functioning; initially unmedicated psychosis; long-term outcome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Waddington, JL Royal Coll Surg Ireland, Dept Clin Pharmacol, 1123 St Stephens Green, Dublin 2, Ireland Royal Coll Surg Ireland 1123 St Stephens GreenDublin Ireland 2
Citazione:
J. Quinn et al., "Long-term adaptive life functioning in relation to initiation of treatmentwith antipsychotics over the lifetime trajectory of schizophrenia", BIOL PSYCHI, 48(2), 2000, pp. 163-166

Abstract

Background: There is evidence that the stage of illness at which antipsychotic treatment is initiated in schizophrenia may have consequences for its subsequent course, How this might relate to impaired adaptive life functioning in the long-term is poorly understood. Methods: Thirty-eight inpatients, many of whom had been admitted in the preneuroleptic era, were assessed using the Social-Adaptive Functioning Evaluation (SAFE); constituent clinical and medication phases of the lifetime trajectory of their illnesses were then analyzed to identify predictors of SAFE score using multiple regression modeling. Results: The primary, independent predictor of SAFE score was duration of initially unmedicated psychosis, which accounted for 22% of variance (p <.001) therein. Conversely, duration of subsequently treated illness, althoughdecades longer, failed to predict SAFE score. Conclusions: These findings are consistent with some form of "progressive"process, particularly over the first several years following the emergenceof pychosis, which is associated with accrual of deficits in adaptive lifefunctioning. Biol Psychiatry 2000;48:163-166 (C) 2000 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:50:27