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Titolo:
An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia
Autore:
Altshuler, LL; Bartzokis, G; Grieder, T; Curran, J; Jimenez, T; Leight, K; Wilkins, J; Gerner, R; Mintz, J;
Indirizzi:
Univ Calif Los Angeles, Mood Disorders Program, Dept Psychiat, Inst Neuropsychiat, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA W Los Angeles Vet Affairs Med Ctr, Psychiat Serv, Los Angeles, CA 90073 USA W Los Angeles Vet Affairs Med Ctr Los Angeles CA USA 90073 , CA 90073 USA Univ Calif Los Angeles, Med Ctr, Dept Radiol Sci, Los Angeles, CA USA UnivCalif Los Angeles Los Angeles CA USA adiol Sci, Los Angeles, CA USA Univ Arkansas Med Sci, Dept Psychiat, Little Rock, AR 72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA Little Rock VA Med Ctr, Psychiat Serv, Little Rock, AR USA Little Rock VA Med Ctr Little Rock AR USA hiat Serv, Little Rock, AR USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 48, anno: 2000,
pagine: 147 - 162
SICI:
0006-3223(20000715)48:2<147:AMSOTL>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; MONOZYGOTIC TWINS DISCORDANT; CAUDATE NUCLEI VOLUMES; CEREBRAL BLOOD-FLOW; MAGNETIC-RESONANCE; VENTRICULAR ENLARGEMENT; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX; BRAIN MORPHOLOGY; BASAL GANGLIA;
Keywords:
amygdala; bipolar; limbic; hippocampus; schizophrenia; temporal lobe;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Altshuler, LL Univ Calif Los Angeles, Mood Disorders Program, Dept Psychiat, Inst Neuropsychiat, 300 UCLA Med Plaza,Suite 1544, Los Angeles, CA 90095USA Univ Calif Los Angeles 300 UCLA Med Plaza,Suite 1544 Los Angeles CA USA 90095
Citazione:
L.L. Altshuler et al., "An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia", BIOL PSYCHI, 48(2), 2000, pp. 147-162

Abstract

Background: Hippocampal atrophy has been described in postmortem and magnetic resonance imaging studies of schizophrenia The specificity of this finding to schizophrenia remains to be determined, The neuropathology of bipolar disorder is understudied, and temporal lobe structures have only recentlybeen evaluated. Methods: Twenty-four bipolar, 20 schizophrenic, and 18 normal comparison subjects were evaluated using magnetic resonance brain imaging, Image data were acquired using a three-dimensional spoiled GRASS sequence, and brain images were reformatted in three planes. Temporal lobe structures including the amygdala, hippocampus, parahippocampus, and total temporal lobe were measured to obtain volumes for each structure in the three subject groups, Severity of symptoms in both patient groups was assessed at the time the magnetic resonance images were obtained. Results: Hippocampal volumes were significantly smaller in rite schizophrenic group than in both bipolar and normal comparison subjects, Further, amygdala volumes were significantly larger in the bipolar group than in both schizophrenic and normal comparison subjects. Conclusions: The results suggest differences in affected limbic structuresin patients with schizophrenia and bipolar disorder. These specific neuroanatomic abnormalities may shed light on the underlying pathophysiology and presentation of the two disorders. Biol Psychiatry 2000; 48:147-162 (C) 2000 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:59:37