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Titolo:
Age and neuropsychologic function in schizophrenia: A decline in executiveabilities beyond that observed in healthy volunteers
Autore:
Fucetola, R; Seidman, LJ; Kremen, WS; Faraone, SV; Goldstein, JM; Tsuang, MT;
Indirizzi:
Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr, Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Ctr, Dept Psychiat, Boston, MA 02115 USA Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Neurol, St Louis, MO 63110 USA Harvard Univ, Sch Med, Dept Psychiat, Brockton W Roxbury Vet Affairs Med Ctr, Brockton, MA 02401 USA Harvard Univ Brockton MA USA 02401 ffairs Med Ctr, Brockton, MA 02401 USA Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Epidemiol & Genet, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Univ Calif Davis, Sch Med, Dept Psychiat, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 ychiat, Sacramento, CA 95817 USA Univ Calif Davis, Napa Psychiat Res Ctr, Napa, CA USA Univ Calif Davis Napa CA USA Davis, Napa Psychiat Res Ctr, Napa, CA USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 48, anno: 2000,
pagine: 137 - 146
SICI:
0006-3223(20000715)48:2<137:AANFIS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
COGNITIVE DECLINE; 1ST-EPISODE SCHIZOPHRENIA; INTELLECTUAL DEFICITS; FIRST-EPISODE; DYSFUNCTION; IMPAIRMENT; MEMORY; STABILITY; DURATION; SYMPTOMS;
Keywords:
schizophrenia; neuropsychology; executive functions; age; deterioration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Seidman, LJ Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr, Dept Psychiat, 74 Fenwood Rd, Boston, MA 02115 USA Harvard Univ 74 Fenwood Rd Boston MA USA 02115 n, MA 02115 USA
Citazione:
R. Fucetola et al., "Age and neuropsychologic function in schizophrenia: A decline in executiveabilities beyond that observed in healthy volunteers", BIOL PSYCHI, 48(2), 2000, pp. 137-146

Abstract

Background: Kraepelin originally conceptualized schizophrenia as a degenerative brain disorder Ir remains unclear whether the illness is characterized bq a static encephalopathy or a deterioration of brain function, or periods of each condition, Assessments of cognitive function, as measured by neuropsychologic assessment, can provide additional insight into this question. Few studies of patients with schizophrenia have investigated the effect of aging on executive functions, in an extensive neuropsychologic battery across a wide age range, compared to healthy volunteers. Methods: We examined the interaction of aging and neuropsychologic function in schizophrenia through a cross-sectional study in patients (n = 87) andhealthy control subjects (n = 94), Subjects were divided into three age groups (20-35 36-49, and 50-75), and performance on an extensive neuropsychologic battery was evaluatedResults: Compared to control subjects, patients with schizophrenia demonstrated similar age-related declines across most neuropsychologic functions, with the exception of abstraction ability, in which significant evidence ofa more accelerated decline was observed. Conclusions: These results are consistent with previous reports indicatingsimilar age effects on most aspects of cognition in patients with schizophrenia and healthy adults, but they support the hypothesis that a degenerative process may result in a more accelerated decline of some executive functions in older age in schizophrenia. Biol Psychiatry 2000; 48:137-146 (C) 2000 Society of Biological Psychiatry.

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Documento generato il 06/04/20 alle ore 01:39:41