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Titolo:
1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT) and reduced bone mineral density
Autore:
Beard, J; Marshall, S; Jong, K; Newton, R; Triplett-McBride, T; Humphries, B; Bronks, R;
Indirizzi:
So Cross Inst Hlth Res, Lismore, NSW 2480, Australia So Cross Inst Hlth Res Lismore NSW Australia 2480 re, NSW 2480, Australia So Cross Univ, Res Coll, Lismore, NSW, Australia So Cross Univ Lismore NSW Australia v, Res Coll, Lismore, NSW, Australia So Cross Univ, Sch Exercise Sci & Sports Management, Lismore, NSW, Australia So Cross Univ Lismore NSW Australia Management, Lismore, NSW, Australia
Titolo Testata:
ARCHIVES OF ENVIRONMENTAL HEALTH
fascicolo: 3, volume: 55, anno: 2000,
pagine: 177 - 180
SICI:
0003-9896(200005/06)55:3<177:1((ARB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR; SERUM; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Beard, J So Cross Inst Hlth Res, POB 498, Lismore, NSW 2480, Australia So Cross Inst Hlth Res POB 498 Lismore NSW Australia 2480 stralia
Citazione:
J. Beard et al., "1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT) and reduced bone mineral density", ARCH ENV HE, 55(3), 2000, pp. 177-180

Abstract

The organochlorine pesticide 1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT), is a well-known and widely dispersed "environmental estrogen" (World Health Organization Criteria no. 9; Geneva, Switzerland [1979]). Kelce et al. (Nature, 1995; 375:581-85) recently identified the DDT metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), has also recently been identified as a potent androgen receptor antagonist. The authors examined the relationship between serum levels of DDE and bone mineral density in 68 sedentary women who reported adequate dietary intake of calcium. Reduced bone mineral density was correlated significantly with age (r = -.36, p = .004), as well as with increases in the log of DDE levels in serum (r = -.27, p= .03). The authors also used multiple-regression analysis to examine the influence of other predictor variables on the relationship between log DDE and bone mineral density. The strongest model (p = .002) included log DDE (p = .018), age (p = .002), and years on hormone replacement therapy (p = .10) as predictor variables, and this model afforded prediction of 21% of bone mineral density variation. These results suggest that past community exposures to DDT may be associated with reduced bone mineral density in women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:12:55