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Titolo:
Method development and validation for the simultaneous determination of fluoxetine and fluvoxamine in pharmaceutical preparations by capillary electrophoresis
Autore:
Nevado, JJB; Salcedo, AMC; Llerena, MJ; Nuevo, EA;
Indirizzi:
Univ Castilla La Mancha, Dept Analyt Chem & Foods Technol, E-13071 Ciudad Real, Spain Univ Castilla La Mancha Ciudad Real Spain E-13071 071 Ciudad Real, Spain
Titolo Testata:
ANALYTICA CHIMICA ACTA
fascicolo: 2, volume: 417, anno: 2000,
pagine: 169 - 176
SICI:
0003-2670(20000724)417:2<169:MDAVFT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; LIQUID-CHROMATOGRAPHY; ULTRAVIOLET DETECTION; NORFLUOXETINE; SERUM;
Keywords:
capillary zone electrophoresis; fluoxetine; fluvoxamine; selective serotonin reuptake inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Nevado, JJB Univ Castilla La Mancha, Dept Analyt Chem & Foods Technol, E-13071 Ciudad Real, Spain Univ Castilla La Mancha Ciudad Real Spain E-13071eal, Spain
Citazione:
J.J.B. Nevado et al., "Method development and validation for the simultaneous determination of fluoxetine and fluvoxamine in pharmaceutical preparations by capillary electrophoresis", ANALYT CHIM, 417(2), 2000, pp. 169-176

Abstract

A capillary zone electrophoresis (CZE) method for determining fluoxetine and fluvoxamine is proposed. Optimal conditions for the quantitative separation were investigated. A background electrolyte solution consisting of 40 mM berate buffer adjusted to pH 9.3, hydrodynamic injection and 8 kV of separation voltage were used, obtaining in these conditions analysis times lower than 2.5 min. Main aspects of the validation method are examined and discussed. Detection limits of 1.0 mg/l for fluoxetine and fluvoxamine were obtained. The developed method is rapid and sensitive and this is the first report on the determination of fluoxetine and fluvoxamine concentrations in pharmaceutical preparations by CZE. Furthermore, the proposed method was applied to nine pharmaceutical preparations with recoveries between 97.75 and 102.95 over their nominal contents. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 26/01/20 alle ore 10:53:54