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Titolo:
Spinal GABA(A) receptors do not mediate the sympathetic baroreceptor reflex in the rat
Autore:
Goodchild, AK; Van Deurzen, BTM; Sun, QJ; Chalmers, J; Pilowsky, PM;
Indirizzi:
Univ Sydney, Royal N Shore Hosp, Dept Physiol, Hypertens & Stroke Res Labs, St Leonards, NSW 2065, Australia Univ Sydney St Leonards NSW Australia 2065 Leonards, NSW 2065, Australia Univ Sydney, Royal N Shore Hosp, Dept Neurosurg, Hypertens & Stroke Res Labs, St Leonards, NSW 2065, Australia Univ Sydney St Leonards NSW Australia2065 Leonards, NSW 2065, Australia
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 1, volume: 279, anno: 2000,
pagine: R320 - R331
SICI:
0363-6119(200007)279:1<R320:SGRDNM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROLATERAL MEDULLA; PREGANGLIONIC NEURONS; INTERMEDIOLATERAL NUCLEUS; CORD; RESPONSES; CAT; ORGANIZATION; BICUCULLINE; STIMULATION; STRYCHNINE;
Keywords:
sympathetic nerve activity; arterial pressure; phrenic nerve discharge; aortic depressor nerve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Pilowsky, PM Univ Sydney, Royal N Shore Hosp, Dept Physiol, Hypertens & Stroke Res Labs, Ground Floor,Block 3, St Leonards, NSW 2065, Australia Univ Sydney Ground Floor,Block 3 St Leonards NSW Australia 2065
Citazione:
A.K. Goodchild et al., "Spinal GABA(A) receptors do not mediate the sympathetic baroreceptor reflex in the rat", AM J P-REG, 279(1), 2000, pp. R320-R331

Abstract

Activation of baroreceptors causes efferent sympathetic nerve activity (SNA) to fall. Two mechanisms could account for this sympathoinhibition: disfacilitation of sympathetic preganglionic neurons (SPN) and/or direct inhibition of SPN. The roles that spinal GABA and glycine receptors play in the baroreceptor reflex were examined in anesthetized, paralyzed, and artificially ventilated rats. Spinal GABA(A) receptors were blocked by an intrathecal injection of bicuculline methiodide, whereas glycine receptors were blockedwith strychnine. Baroreceptors were activated by stimulation of the aorticdepressor nerve (ADN), and a somatosympathetic reflex was used as control. After an intrathecal injection of vehicle, there was no effect on any measured variable or evoked reflex. In contrast, bicuculline caused a dose-dependent increase in arterial pressure, SNA, phrenic nerve discharge, and it significantly facilitated the somatosympathetic reflex. However, bicucullinedid not attenuate either the depressor response or sympathoinhibition evoked after ADN stimulation. Similarly, strychnine did not affect the baroreceptor-induced depressor response. Thus GABA(A) and glycine receptors in the spinal cord have no significant role in baroreceptor-mediated sympathoinhibition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:23:21