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Titolo:
Effect of acute hypoxia on vasopressin release and intravascular fluid during dynamic exercise in humans
Autore:
Takamata, A; Nose, H; Kinoshita, T; Hirose, M; Itoh, T; Morimoto, T;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Physiol, Kamigyo Ku, Kyoto 6020841, JapanKyoto Prefectural Univ Med Kyoto Japan 6020841 Ku, Kyoto 6020841, Japan Shinshu Univ, Sch Med, Dept Sports Med, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 1, volume: 279, anno: 2000,
pagine: R161 - R168
SICI:
0363-6119(200007)279:1<R161:EOAHOV>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-DIURETIC HORMONE; GRADED-EXERCISE; RENIN-ACTIVITY; PLASMA-VOLUME; RESPONSES; ELECTROLYTE; ALDOSTERONE; DEHYDRATION; SHIFT; BLOOD;
Keywords:
arginine vasopressin; plasma osmolality; plasma volume; normobaric hypoxia; exercise intensity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Takamata, A Kyoto Prefectural Univ Med, Dept Physiol, Kamigyo Ku, Kyoto 6020841, Japan Kyoto Prefectural Univ Med Kyoto Japan 6020841 020841, Japan
Citazione:
A. Takamata et al., "Effect of acute hypoxia on vasopressin release and intravascular fluid during dynamic exercise in humans", AM J P-REG, 279(1), 2000, pp. R161-R168

Abstract

To test the hypothesis that acute hypoxia does not modify the relationshipbetween plasma vasopressin concentration ([AVP](p)) and plasma osmolality (P-osmol) during exercise and that the increase in [AVP](p) during exerciseis due mainly to the exercise intensity-dependent increase in P-osmol, we examined [AVP](p) during a graded exercise in a hypoxic condition (13% O-2,N-2 balance) in seven healthy male subjects. A graded exercise in a normoxic condition on a separate day served as the control. Hypoxia reduced peak aerobic power ((V) over dotO(2 peak)) by 32.4 +/- 2.7%. Blood samples obtained during rest and at around 25, 45, 65, 80, and 100% of (V) over dotO(2) (peak) of each of the respective conditions were used for analyses of intravascular water and electrolyte balance. The pattern of the changes in fluidand electrolyte balance in response to percent (V) over dotO(2 peak) was similar between the two conditions. Plasma volume decreased linearly as percent (V) over dotO(2 peak) increased while P-osmol increased in a curvilinear fashion with a steep increase occurring at above similar to 66% (V) over dotO(2 peak). Above this relative exercise intensity, plasma sodium, potassium, and lactate concentrations also increased, whereas plasma bicarbonate concentration decreased. Thus transvascular fluid movement at above similarto 66% (V) over dotO(2 peak) was due to the net efflux of hypotonic fluid out of the vascular space in both conditions. The relationship between [AVP](p) and P-osmol during exercise in response to relative exercise intensitywas similar between the two conditions. The results indicate that acute mild hypoxia itself has no direct effect on vasopressin release, and it does not modify the relationship between [AVP](p) and P-osmol during exercise. The results also support the hypothesis that exercise-induced vasopressin release is primarily stimulated by increased P-osmol produced by hypotonic fluid movement out of the vascular space in a relative exercise intensity-dependent manner.

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Documento generato il 30/03/20 alle ore 19:36:21