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Titolo:
Electrical stimulation of afferent vagus nerve induces IL-1 beta expression in the brain and activates HPA axis
Autore:
Hosoi, T; Okuma, Y; Nomura, Y;
Indirizzi:
Hokkaido Univ, Grad Sch Pharmaceut Sci, Dept Pharmacol, Sapporo, Hokkaido 0600812, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600812 oro, Hokkaido 0600812, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 1, volume: 279, anno: 2000,
pagine: R141 - R147
SICI:
0363-6119(200007)279:1<R141:ESOAVN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; VAGAL-MEDIATED MECHANISM; GASTRIC-ACID SECRETION; SUBDIAPHRAGMATIC VAGOTOMY; MESSENGER-RNA; PERIPHERAL LIPOPOLYSACCHARIDE; INTERLEUKIN-1; RATS; NEURONS; FEVER;
Keywords:
corticotropin-releasing factor; adrenocorticotrophic hormone; corticosterone; lipopolysaccharide; neuroimmune interaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Okuma, Y Hokkaido Univ, Grad Sch Pharmaceut Sci, Dept Pharmacol, Sapporo, Hokkaido 0600812, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600812 aido 0600812, Japan
Citazione:
T. Hosoi et al., "Electrical stimulation of afferent vagus nerve induces IL-1 beta expression in the brain and activates HPA axis", AM J P-REG, 279(1), 2000, pp. R141-R147

Abstract

Possible roles of the afferent vagus nerve in regulation of interleukin (IL)-1 beta expression in the brain and hypothalamic-pituitary-adrenal (HPA) axis were examined in anesthetized rats. Levels of IL-1 beta mRNA and protein in the brain were measured by comparative RT-PCR and ELISA. Direct electrical stimulation of the central end of the vagus nerve was performed continuously for 2 h. The afferent stimulation of the vagus nerve induced increases in the expression of mRNA and protein levels of IL-1 beta in the hypothalamus and the hippocampus. Furthermore, expression of corticotropin-releasing factor mRNA was increased in the hypothalamus 2 h after vagal stimulation. Plasma levels of ACTH and corticosterone were also increased by this stimulation. The present results indicate that activation of the afferent vagus nerves itself can induce production of IL-1 beta in the brain and activate the HPA axis. Therefore, the afferent vagus nerve may play an important role in transmitting peripheral signals to the brain in the infection and inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:36:07