Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Receptor subtypes mediating depressor responses to microinjections of nicotine into medial NTS of the rat
Autore:
Dhar, S; Nagy, F; McIntosh, JM; Sapru, HN;
Indirizzi:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosurg, Newark, NJ07103 USA Univ Med & Dent New Jersey Newark NJ USA 07103 osurg, Newark, NJ07103 USA Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 Biol, Salt Lake City, UT 84112 USA Univ Utah, Dept Psychiat, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 chiat, Salt Lake City, UT 84112 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 1, volume: 279, anno: 2000,
pagine: R132 - R140
SICI:
0363-6119(200007)279:1<R132:RSMDRT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; IN-VIVO MICRODIALYSIS; ALPHA-CONOTOXIN-IMI; ACETYLCHOLINE-RECEPTORS; BLOOD-PRESSURE; CARDIAC RESPONSES; AMINO-ACIDS; SPINAL-CORD; BUNGAROTOXIN; MECHANISMS;
Keywords:
blood pressure; bradycardia; heart rate; hexamethonium; mecamylamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Sapru, HN Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosurg, MSB H-586,185 S Orange Ave, Newark, NJ 07103 USA Univ Med & Dent New JerseyMSB H-586,185 S Orange Ave Newark NJ USA 07103
Citazione:
S. Dhar et al., "Receptor subtypes mediating depressor responses to microinjections of nicotine into medial NTS of the rat", AM J P-REG, 279(1), 2000, pp. R132-R140

Abstract

Microinjections (50 nl) of nicotine (0.01-10 mM) into the nucleus of the solitary tract (NTS) of adult, urethan-anesthetized, artificially ventilated, male Wistar rats, elicited decreases in blood pressure and heart rate. Prior microinjections of alpha-bungarotoxin (alpha-BT) and alpha-conotoxin ImI (specific toxins for nicotinic receptors containing alpha 7 subunits) elicited a 20-38% reduction in nicotine responses. Similarly, prior microinjections of hexamethonium, mecamylamine, and alpha-conotoxin AuIB (specific blockers or toxin for nicotinic receptors containing alpha 3 beta 4 subunits)elicited a 47-79% reduction in nicotine responses. Nicotine responses werecompletely blocked by prior sequential microinjections of alpha-BT and mecamylamine into the NTS. Complete blockade of excitatory amino acid receptors (EAARs) in the NTS did not attenuate the responses to nicotine. It was concluded that 1) the predominant type of nicotinic receptor in the NTS contains alpha 3 beta 4 subunits, 2) a smaller proportion contains alpha 7 subunits, 3) the presynaptic nicotinic receptors in the NTS do not contribute tonicotine-induced responses, and 4) EAARs in the NTS are not involved in mediating responses to nicotine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:16:46