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Titolo:
Diameter changes in skeletal muscle venules during arterial pressure reduction
Autore:
Bishop, JJ; Nance, PR; Popel, AS; Intaglietta, M; Johnson, PC;
Indirizzi:
Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ioengn, La Jolla, CA 92093 USA Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 d Engn, Baltimore, MD 21205 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 1, volume: 279, anno: 2000,
pagine: H47 - H57
SICI:
0363-6135(200007)279:1<H47:DCISMV>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROVASCULAR MEASUREMENTS; BLOOD; FLOW; MICROVESSELS; RESPONSES; SHEARING;
Keywords:
venous resistance; venous pressure; venous collapse; venous wall architecture; hemorrhage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, PC Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 olla, CA 92093 USA
Citazione:
J.J. Bishop et al., "Diameter changes in skeletal muscle venules during arterial pressure reduction", AM J P-HEAR, 279(1), 2000, pp. H47-H57

Abstract

Previous studies in skeletal muscle have shown a substantial (>100%) increase in venous vascular resistance with arterial pressure reduction to 40 mmHg, but a microcirculatory study showed no significant venular diameter changes in the horizontal direction during this procedure. To examine the possibility of venular collapse in the vertical direction, a microscope was placed horizontally to view a vertically mounted rat spinotrapezius muscle preparation. We monitored the diameters of venules (mean diameter 73.8 +/- 37.0 mm, range 13-185 mu m) oriented horizontally and vertically with a video system during acute arterial pressure reduction by hemorrhage. Our analysisshowed small but significant (P< 0.0001) diameter reductions of 1.0 +/- 2.5 mu m and 1.8 +/- 3.1 mu m in horizontally and vertically oriented venules, respectively, upon reduction of arterial pressure from 115.0 +/- 26.3 to 39.8 +/- 12.3 mmHg. The venular responses were not different after red blood cell aggregation was induced by Dextran 500 infusion. We conclude that diameter changes in venules over this range of arterial pressure reduction are isotropic and would likely increase venous resistance by <10%.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:29:24