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Titolo:
Apolipoprotein-E and white matter hyperintensities in late-life depression
Autore:
Lavretsky, H; Lesser, IM; Wohl, M; Miller, BL; Mehringer, CM; Vinters, HV;
Indirizzi:
Univ Calif Los Angeles, Inst Neuropsychiat, Sch Med, Dept Psychiat, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
fascicolo: 3, volume: 8, anno: 2000,
pagine: 257 - 261
SICI:
1064-7481(200022)8:3<257:AAWMHI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MEDICAL ILLNESS; GERIATRIC DEPRESSION; SIGNAL HYPERINTENSITIES; MAJOR DEPRESSION; RATING-SCALE; LATE-ONSET; DISEASE; BRAIN; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Lavretsky, H Univ Calif Los Angeles, Inst Neuropsychiat, Sch Med, Dept Psychiat, Room 37-425,760 Westwood Pl, Los Angeles, CA 90024 USA Univ Calif Los Angeles Room 37-425,760 Westwood Pl Los Angeles CA USA 90024
Citazione:
H. Lavretsky et al., "Apolipoprotein-E and white matter hyperintensities in late-life depression", AM J GER PS, 8(3), 2000, pp. 257-261

Abstract

The authors conducted a follow-up study of 16 patients with late-life depression approximately 6 years after their initial assessment to evaluate therelationships between apolipoprotein-E (APO-E) status and white-matter hyperintensities (WMH). Ten patients had WMH at baseline, and four patients demonstrated cm increase in WMH size over time. Three of four patients with the APO-E epsilon 4 allele demonstrated an increase in WMH over time, and only I of 12 patients Without an epsilon 4 allele had an increase in WMH. Three of four patients with APO-E epsilon 4 allele developed a chronic course of major depression at follow-up. Patients with APO-E epsilon 4 had a higher number of depressive episodes and lower age at onset. APO-E may be a riskfactor for cerebrovascular disease associated with late-life depression and may affect the clinical characteristics and disease course of depression.

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Documento generato il 05/04/20 alle ore 19:23:29