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Titolo:
Serotonergic function, behavioral disinhibition, and negative affect in children of alcoholics: The moderating effects of puberty
Autore:
Twitchell, GR; Hanna, GL; Cook, EH; Fitzgerald, HE; Zucker, RA;
Indirizzi:
Michigan State Univ, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 Univ, E Lansing, MI 48824 USA Univ Michigan, Alcohol Res Ctr, Ann Arbor, MI 48109 USA Univ Michigan AnnArbor MI USA 48109 hol Res Ctr, Ann Arbor, MI 48109 USA Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 pt Psychiat, Ann Arbor, MI 48109 USA Univ Chicago, Dept Psychiat, Lab Dev Neurosci, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 Lab Dev Neurosci, Chicago, IL 60637 USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 7, volume: 24, anno: 2000,
pagine: 972 - 979
SICI:
0145-6008(200007)24:7<972:SFBDAN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUID 5-HYDROXYINDOLEACETIC ACID; DEFICIT HYPERACTIVITY DISORDER; WHOLE-BLOOD SEROTONIN; ANXIETY-RELATED TRAITS; AGE-RELATED-CHANGES; NEUROENDOCRINE RESPONSE; MONOAMINE METABOLITES; IMIPRAMINE BINDING; TRANSPORTER GENE; MIDDLE CHILDHOOD;
Keywords:
whole blood serotonin (5-HT); behavioral disinhibition; negative affect; children of alcoholics; biological markers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Twitchell, GR Univ Calif Los Angeles, Drug Abuse Res Ctr, 1640 S Sepulveda,Suite 200, Los Angeles, CA 90025 USA Univ Calif Los Angeles 1640 S Sepulveda,Suite 200 Los Angeles CA USA 90025
Citazione:
G.R. Twitchell et al., "Serotonergic function, behavioral disinhibition, and negative affect in children of alcoholics: The moderating effects of puberty", ALC CLIN EX, 24(7), 2000, pp. 972-979

Abstract

Background: Serotonergic (5-HT) dysfunction has been implicated in both behavioral disinhibition and negative affect in adults. Although our group's previous work found decreased whole blood 5-HT in high versus low behavior problem children of alcoholics, some child/adolescent studies report conflicting results, and 5-HT's role in negative affect has been largely unexamined. Age-related developmental factors may play a role in these relationships. Methods: This report is from an ongoing prospective study of the development of risk for alcohol abuse/dependence and other problematic outcomes in asample of families subtyped by father's alcoholism classification. The present study extends previous work and examines relationships between whole blood 5-HT and both child behavioral disinhibition (an aggression index fromthe Child Behavior Checklist) and negative affect (Child Behavior Checklist Anxious/Depressed scale) in offspring from 47 families (N = 45 boys and 17 girls, mean age = 10.88 +/- 2.03 yr). Results: The most important finding was that puberty moderated relationships between 5-HT and both behavioral disinhibition and negative affect with a relationship for pubescent children (n = 14, r = -0.54, p = 0.05; r. = -0.57, p = 0.04, respectively) but no relationship for prepubescent children (n = 48, r = 0.05, p = 0.75; r = -0.15,p = 0.31, respectively). Conclusions: The moderating effects of puberty may help clarify inconsistencies in child/adolescent literature. Furthermore, there appears to be a relationship between 5-HT and negative affect which parallels that between 5-HT and behavioral disinhibition. Pubertal status may be an important variable to evaluate as a moderator in relation to the developmental context of the role 5-HT dysfunction may play in various models of behavior related to alcoholism over the early life course.

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Documento generato il 18/01/20 alle ore 08:20:20