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Titolo:
Angiogenesis in a patient with ischemic limb - Induced by intramuscular injection of vascular endothelial growth factor and fibrin platform
Autore:
Kipshidze, N; Chekanov, V; Chawla, P; Shanker, LR; Gosset, JB; Kumar, K; Hammen, D; Gordon, J; Keelan, MH;
Indirizzi:
Med Coll Wisconsin, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 consin, Milwaukee, WI 53226 USA
Titolo Testata:
TEXAS HEART INSTITUTE JOURNAL
fascicolo: 2, volume: 27, anno: 2000,
pagine: 196 - 200
SICI:
0730-2347(2000)27:2<196:AIAPWI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL ARTERY DISEASE; THERAPEUTIC ANGIOGENESIS; KAWASAKI-DISEASE; GENE-TRANSFER; RABBIT MODEL; MYOCARDIAL ANGIOGENESIS; CAPILLARY INGROWTH; GLUE; REVASCULARIZATION; PERFUSION;
Keywords:
endothelial growth factors/therapeutic use; ischemia/therapy; leg/blood supply; neovascularization, physiologic/drug effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Kipshidze, N Lenox Hill Hosp, 9th Floor,130 77th St, New York, NY 10021 USA Lenox Hill Hosp 9th Floor,130 77th St New York NY USA 10021 A
Citazione:
N. Kipshidze et al., "Angiogenesis in a patient with ischemic limb - Induced by intramuscular injection of vascular endothelial growth factor and fibrin platform", TEX HEART I, 27(2), 2000, pp. 196-200

Abstract

Direct revascularization of critical ischemia of the limb is often unsuccessful due to the anatomic extent an distribution of arterial occlusive disease, and no pharmacologic treatment has proved effective in treating this condition. Patients with ischemic limb may eventually require amputation andmay develop serious morbidity and mortality. The goal of limb salvage in these patients has stimulated research into alternative treatment methods, including angiogenesis. Attempts have been made to apply growth factors directly or to encode DNA for such factors, but it is unknown whether these factors remain at the target site long enough to be effective. We report our strategy of using vascular endothelial growth factor in a network, which enables the sustained release of biologic material at the target site.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:53:34