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Titolo:
Rab1 recruitment of p115 into a cis-SNARE complex: Programming budding COPII vesicles for fusion
Autore:
Allan, BB; Moyer, BD; Balch, WE;
Indirizzi:
Scripps Clin & Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA Scripps Clin & Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA
Titolo Testata:
SCIENCE
fascicolo: 5478, volume: 289, anno: 2000,
pagine: 444 - 448
SICI:
0036-8075(20000721)289:5478<444:RROPIA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE DISSOCIATION INHIBITOR; ENDOCYTIC MEMBRANE-FUSION; ENDOPLASMIC-RETICULUM; GOLGI TRANSPORT; VESICULAR TRANSPORT; T-SNARE; PROTEIN-TRANSPORT; CARRIER VESICLES; REQUIRES USO1P; IN-VITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Balch, WE Scripps Clin & Res Inst, Dept Cell Biol, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA Scripps Clin & Res Inst 10550 N Torrey Pines Rd LaJolla CA USA 92037
Citazione:
B.B. Allan et al., "Rab1 recruitment of p115 into a cis-SNARE complex: Programming budding COPII vesicles for fusion", SCIENCE, 289(5478), 2000, pp. 444-448

Abstract

The guanosine triphosphatase Rab1 regulates the transport of newly synthesized proteins from the endoplasmic reticulum to the Golgi apparatus throughinteraction with effector molecules, but the molecular mechanisms by whichthis occurs are unknown. Here, the tethering factor p115 was shown to be aRab1 effector that binds directly to activated Rab1. Rab1 recruited p115 to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacted with a select set of COPII vesicle-associated SNAREs (soluble N-ethylmateimide-sensitive factor attachment protein receptors) to form a cis-SNARE complex that promotes targeting to the Golgiapparatus. We propose that Rab1-regulated assembly of functional effector-SNARE complexes defines a conserved molecular mechanism to coordinate recognition between subcellular compartments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 03:52:57