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Titolo:
Habituation of the blink reflex in first-episode schizophrenia, psychotic depression and non-psychotic depression
Autore:
Taiminen, T; Jaaskelainen, S; Ilonen, T; Meyer, H; Karlsson, H; Lauerma, H; Leinonen, KM; Wallenius, E; Kaljonen, A; Salokangas, RKR;
Indirizzi:
Univ Turku, Dept Psychiat, FIN-20700 Turku, Finland Univ Turku Turku Finland FIN-20700 pt Psychiat, FIN-20700 Turku, Finland Univ Turku, Cent Hosp, Dept Clin Neurophysiol, Turku, Finland Univ Turku Turku Finland t Hosp, Dept Clin Neurophysiol, Turku, Finland Univ Turku, Cent Hosp, Dept Psychiat, Turku, Finland Univ Turku Turku Finland urku, Cent Hosp, Dept Psychiat, Turku, Finland Abo Akad Univ, Dept Psychol, Turku, Finland Abo Akad Univ Turku FinlandAbo Akad Univ, Dept Psychol, Turku, Finland Psychiat Hosp Prisoners, Turku, Finland Psychiat Hosp Prisoners Turku Finland at Hosp Prisoners, Turku, Finland
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 44, anno: 2000,
pagine: 69 - 79
SICI:
0920-9964(20000707)44:1<69:HOTBRI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
STARTLE REFLEX; PREPULSE INHIBITION; NORMAL VALUES; IN-VIVO; DISORDER; DEFICITS; DIAGNOSIS; MODELS; SCALE;
Keywords:
blink reflex; depression; dopamine; habituation; psychosis; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Taiminen, T Univ Turku, Dept Psychiat, Kunnallissairaalantie 20, FIN-20700Turku, Finland Univ Turku Kunnallissairaalantie 20 Turku Finland FIN-20700 d
Citazione:
T. Taiminen et al., "Habituation of the blink reflex in first-episode schizophrenia, psychotic depression and non-psychotic depression", SCHIZOPHR R, 44(1), 2000, pp. 69-79

Abstract

Objective: Electrophysiological recording of the electrically elicited blink reflex is the most reliable method of investigating habituation of the startle reflex. The purpose of this study was to compare the habituation andthe late R3-component of the blink reflex between control subjects (N = 19) and first-episode patients with schizophrenia (N = 17), psychotic depression (N = 23), and severe non-psychotic depression (N = 25). Methods: The blink reflex was evoked by electrical stimulation of the supraorbital nerve, and the deficient habituation of the R2i-component was measured with a computer-assisted integral area measurement. Prefrontal executive function of the patients was assessed with the Wisconsin Card Sorting Test. Current psychiatric symptoms were assessed with the Brief Psychiatric Rating Scale, theHamilton Depression Scale, the Positive and Negative Syndrome Scale, and the Calgary Depression Scale. Results: Deficient habituation of the blink reflex and occurrence of the late R3 component were associated both with a previous diagnosis of psychotic disorder and with the presence of current psychosis. The sensitivity and specificity of the abnormal habituation of the blink reflex in detecting psychotic disorder were 0.50 and 0.80, respectively. The abnormalities of the blink reflex were not associated with psychotropic medication. In schizophrenic patients, defective habituation of the blink reflex was associated with negative and cognitive symptoms, and in depressive patients with the presence of delusions. Conclusions: The deficient habituation of the blink reflex and occurrence of the late R3 component seem to be both trait and state markers of a psychotic disorder. The results suggest that schizophrenia and psychotic depression share some common neurobiological mechanisms involved in the modulation of the startle reflex. (C) 2000 Elsevier Science B.V. FLU rights reserved.

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Documento generato il 18/01/20 alle ore 02:39:20