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Titolo:
Serotonin(2A) receptors are reduced in the planum temporale from subjects with schizophrenia
Autore:
Pralong, D; Tomaskovic-Crook, E; Opeskin, K; Copolov, D; Dean, B;
Indirizzi:
Mental Hlth Res Inst, Div Mol Schizophrenia, Rebecca L Cooper Res Labs, Parkville, Vic 3052, Australia Mental Hlth Res Inst Parkville Vic Australia 3052 le, Vic 3052, Australia
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 44, anno: 2000,
pagine: 35 - 45
SICI:
0920-9964(20000707)44:1<35:SRARIT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CEREBRAL-CORTEX; ANTIPSYCHOTIC-DRUGS; 5-HT2 RECEPTORS; HUMAN-BRAIN; BLOOD-FLOW; POSTMORTEM; BINDING; CHLORPROMAZINE; HALLUCINATIONS; ASYMMETRY;
Keywords:
antipsychotic; autoradiography; [3H]ketanserin; 5HT2A; Planum temporale; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Pralong, D Mental Hlth Res Inst, Div Mol Schizophrenia, Rebecca L Cooper Res Labs, Parkville, Vic 3052, Australia Mental Hlth Res Inst Parkville VicAustralia 3052 2, Australia
Citazione:
D. Pralong et al., "Serotonin(2A) receptors are reduced in the planum temporale from subjects with schizophrenia", SCHIZOPHR R, 44(1), 2000, pp. 35-45

Abstract

[H-3]ketanserin binding to 5HT(2A) receptors was measured in the left planum temporale (sensory speech cortex) from schizophrenic and non-schizophrenic (control) subjects using both particulate membranes and tissue sections. There was a significant decrease in the affinity of [H-3]ketanserin binding to particulate membranes from schizophrenic subjects who were treated with phenothiazines up to death. Adding 2 nM chlorpromazine to brain tissue from control subjects caused a similar decrease in the affinity of [H-3]ketanserin binding to particulate membranes. This suggests that the decrease in affinity observed in the phenothiazine-treated subjects was due to residualdrugs. In addition, there was a significant decrease in the density of [H-3]ketanserin binding in both particulate membranes and tissue sections fromschizophrenic subjects which did not appear to be due to residual antipsychotic drugs. Analysis of the laminar distribution of 5HT(2A) receptors showed that this decrease was greatest in cortical layer III. The decrease in the density of 5HT(2A) receptors was significant whether schizophrenic subjects were receiving phenothiazines or haloperidol at the time of death, and there was no correlation between the last recorded dose of antipsychotic drug and 5HT(2A) receptor density. These data suggest that a decrease in the density of 5HT(2A) receptors in the planum temporale may be associated withthe pathology of schizophrenia. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:21:25