Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: Synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions
Autore:
Zhao, WQ; Cavallaro, S; Gusev, P; Alkon, DL;
Indirizzi:
NINDS, Lab Adapt Syst, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 , Lab Adapt Syst, NIH, Bethesda, MD 20892 USA CNR, Inst Bioimaging & Pathophysiol Cent Nervous Syst, I-95123 Catania, Italy CNR Catania Italy I-95123 siol Cent Nervous Syst, I-95123 Catania, Italy
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 14, volume: 97, anno: 2000,
pagine: 8098 - 8103
SICI:
0027-8424(20000705)97:14<8098:NTPKPI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; GROWTH CONE MEMBRANES; DEVELOPING RAT-BRAIN; C-SRC; NEUROTRANSMITTER RELEASE; NMDA RECEPTORS; PRODUCT; NEURONS; BINDING; VESICLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Zhao, WQ NINDS, Lab Adapt Syst, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 pt Syst, NIH, Bethesda, MD 20892 USA
Citazione:
W.Q. Zhao et al., "Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: Synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions", P NAS US, 97(14), 2000, pp. 8098-8103

Abstract

c-src is a nonreceptor tyrosine protein kinase that is highly concentratedin synaptic regions, including synaptic vesicles and growth cones. Here, we report that the mRNA signal of pp60c-src is widely distributed in the ratbrain with particularly high concentrations in the hippocampus. After spatial maze learning, up-regulation of c-src mRNA was observed in the CA3 region of the hippocampus, which was accompanied by increases in pp60c-src protein in hippocampal synaptosomal preparations. Training also triggered an increase in c-src protein tyrosine kinase activity that was correlated with its tyrosine dephosphorylation in the synaptic membrane fraction, After training, pp60c-src from hippocampus showed enhanced interactions with synapticproteins such as synapsin I, synaptophysin, and the type 2 N-methyl-D-aspartate receptor, as well as the cytoskeletal protein actin, The association of pp60c-src with insulin receptor in the synaptic membrane fraction, however, was temporally decreased after training. Furthermore, in vitro results showed that Ca2+ and protein kinase C might be involved in the regulation of protein-protein interactions of pp60c-src. These results suggest, therefore, that pp60c-src participates in the regulation of hippocampal synaptic activity during learning and memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:03:12