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Titolo:
Hypothalamic-pituitary-adrenal axis in long-term inhaled corticosteroid therapy for nasal polyposis
Autore:
Amanou, L; Avan, P; Valcke, JC; Bonfils, P;
Indirizzi:
Hop Bouccicaut, Serv ORL & Chirurg Cervicofaciale, F-75015 Paris, France Hop Bouccicaut Paris France F-75015 ervicofaciale, F-75015 Paris, France Univ Paris 05, Fac Necker Enfants Malad, Hop Europeen Georges Pompidou, Paris, France Univ Paris 05 Paris France Hop Europeen Georges Pompidou, Paris, France Univ Auvergne, Fac Med, Serv Biophys & Biostat, Clermont Ferrand, France Univ Auvergne Clermont Ferrand France Biostat, Clermont Ferrand, France
Titolo Testata:
PRESSE MEDICALE
fascicolo: 22, volume: 29, anno: 2000,
pagine: 1214 - 1216
SICI:
0755-4982(20000624)29:22<1214:HAILIC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
FRE
Soggetto:
NORMAL CORTISOL RESPONSE; SHORT SYNACTHEN; ACTH TEST; SUPPRESSION; FAILURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Bonfils, P Hop Bouccicaut, Serv ORL & Chirurg Cervicofaciale, 78 Rue Convention, F-75015 Paris, France Hop Bouccicaut 78 Rue Convention Paris FranceF-75015 , France
Citazione:
L. Amanou et al., "Hypothalamic-pituitary-adrenal axis in long-term inhaled corticosteroid therapy for nasal polyposis", PRESSE MED, 29(22), 2000, pp. 1214-1216

Abstract

OBJECTIVE: To assess the hypothalamic-pituitary-adrenal (HPA) axis after long-term intranasal corticosteroid treatment in nasal polyposis. PATIENTS AND METHODS: A short synacthen test was performed in 24 patients who received the highest dose of inhaled beclomethasone among a population of 392 patients treated for nasal polyposis with inhaled corticosteroid therapy and short-term oral corticosteroids. RESULTS: Mean yearly dose of oral prednisone administered in shortterm treatment was 371 mg/year. The amount of short-term oral prednisone decreased during the treatment Mean daily dose of inhaled beclomethasone was 2861 mu g/day, decreasing during treatment Morning plasma cortisol was normal in all patients before and after stimulation (163 +/- 44 and 1 +/- 60 mu g/ml respectively), Nolomethasone dose and plasma cortisol level before or after stimulation. DISCUSSION: The high dose of inhaled bedomethasone used to treat nasal polyposis does not affect the HPA axis. Some authors in the literature contestthe validity of short synacthen test to detect HPA axis suppression. This test does however detect severe impairments of the HPA axis in outpatients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:40:30