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Titolo:
Behavioral effects of 8-OH-DPAT in chronically stressed male and female rats
Autore:
Sipos, ML; Bauman, RA; Widholm, JJ; Kant, GJ;
Indirizzi:
Walter Reed Army Inst Res, Div Neurosci, Washington, DC 20307 USA Walter Reed Army Inst Res Washington DC USA 20307 ashington, DC 20307 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2, volume: 66, anno: 2000,
pagine: 403 - 411
SICI:
0091-3057(200006)66:2<403:BEO8IC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE REFLEX; GULF-WAR VETERANS; 5-HYDROXYINDOLEACETIC ACID; AUTORADIOGRAPHIC ANALYSES; PREPULSE INHIBITION; DORSAL HIPPOCAMPUS; LOCOMOTOR-ACTIVITY; RECEPTOR AGONISTS; SUSTAINED STRESS; 5-HT1A RECEPTORS;
Keywords:
serotonin chronic stress; locomotor activity; figure-8 maze; acoustic startle response; 8-OH-DPAT; 5-HT1A receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Sipos, ML USA, Med Res Inst Chem Def, Drug Assessment Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA USA 3100 Ricketts Point Rd Aberdeen Proving Ground MD USA 21010
Citazione:
M.L. Sipos et al., "Behavioral effects of 8-OH-DPAT in chronically stressed male and female rats", PHARM BIO B, 66(2), 2000, pp. 403-411

Abstract

The present study tested the hypothesis that chronic stress desensitizes serotonergic 5-HT1A receptors and alters behavioral changes following 5-HT1Aagonist administration. Eating, acoustic startle response (ASR), and locomotor activity were measured in stressed and nonstressed male and female rats after 8-OH-DPAT administration. Stressed rats were paired and stressed byaround-the-clock intermittent foot shock. Controllable stress (CS) rats could avoid/terminate shock for themselves and their yoked partners by pulling a ceiling chain, whereas their partners, the uncontrollable stress (UCS) rats, could not. Rats earned their entire daily ration of food by pressing a lever. In previous experiments, this paradigm was stressful, but not debilitating and rats continued to eat, groom, sleep, and avoid/escape greater than 99% of shock trials. Locomotor activity and ASR were measured in the present study after saline and 8-OH-DPAT administration (0.25 mg/kg, IP) before, 24 h, and 72 h after shock onset. 8-OH-DPAT only decreased food intakesignificantly in male and female rats after the first administration. Stress decreased food intake in both the CS and UCS rats, with UCS rats eating the least. However, the effects of stress and 8-OH-DPAT were not additive. 8-OH-DPAT significantly increased peak startle amplitude at 100 and 120 dB,and decreased latency to peak startle amplitude at 100 dB in male and female rats. In contrast, 8-OH-DPAT did not alter percent prepulse inhibition (%PPI) at 100 dB, but significantly decreased %PPI in males but not females at 120 dB. Stress did not have a consistent effect on ASR, but reduced %PPIin males, but not females. Neither stress nor 8-OH-DPAT significantly altered locomotor activity. Although the results do not show an increased sensitivity to 8-OH-DPAT in stressed rats, the unexpectedly weak effects of 8-OH-DPAT alone on the behavioral measures chosen limits the conclusions that can be drawn. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/02/20 alle ore 11:45:45