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Titolo:
The importance of acclimation in acoustic startle amplitude and pre-pulse inhibition testing of male and female rats
Autore:
Faraday, MM; Grunberg, NE;
Indirizzi:
Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA Uniformed Serv Univ Hlth Sci Bethesda MD USA 20814 Bethesda, MD 20814 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2, volume: 66, anno: 2000,
pagine: 375 - 381
SICI:
0091-3057(200006)66:2<375:TIOAIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPULSE INHIBITION; ULTRASONIC VOCALIZATION; GENETIC INFLUENCES; NICOTINE; STRESS; RESPONSES; HABITUATION; DIAZEPAM; REFLEX; MODULATION;
Keywords:
acoustic startle reflex; pre-pulse inhibition; testing environment; sex differences; Sprague-Dawley rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Faraday, MM Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA Uniformed Serv Univ Hlth Sci 4301 Jones Bridge Rd Bethesda MD USA 20814
Citazione:
M.M. Faraday e N.E. Grunberg, "The importance of acclimation in acoustic startle amplitude and pre-pulse inhibition testing of male and female rats", PHARM BIO B, 66(2), 2000, pp. 375-381

Abstract

The acoustic startle reflex (ASR) and pre-pulse inhibition (PPI) of the ASR are used extensively to index drug effects in rodents. Important methodological issues exist, however, with regard to the specific procedures and equipment used. In particular, the effects of acclimation to the startle procedure on response stability and the effects of testing animals in groups vs, individually have not been examined but are relevant to data interpretation. The present experiment measured acoustic startle responses with and without a pre-pulse of 25 adult Sprague-Dawley rats (12 male, 13 female) tested individually and in same-sex groups at four time points. Individual testing increased startle responses and PPI of males at time 1 and altered PPI of females at times 1, 2, and 3 compared with group testing. Responses were indistinguishable in the two testing environments at time 4. Results indicate that testing environment may affect responses when subjects have not been acclimated to the testing situation and that there are sex differences inthese effects. Because responses stabilized by the fourth testing point, repeated testing of subjects particularly females, may be an important methodological inclusion when evaluating effects of drugs and other manipulations on ASR and PPI. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:01:41